Peripheral blood cytotoxic T cells in patients with sarcoidosis
- 作者: Lazareva N.1,2, Kudryavtsev I.1,3, Baranova O.1, Serebriakova M.3, Ses’ T.1,2, Ilkovich M.1, Totolyan A.1,4
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隶属关系:
- Academician I.P. Pavlov First St. Petersburg State Medical University
- State Research Institute of Highly Pure Biopreparations
- Institute of Experimental Medicine
- St. Petersburg Pasteur Institute
- 期: 卷 21, 编号 3 (2018)
- 页面: 348-353
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119884
- DOI: https://doi.org/10.31857/S102872210002408-3
- ID: 119884
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Based on CD45RA, CD62L, CD27 и CD28 expression several subsets of peripheral blood CD3+CD8+ lymphocytes were measured in patients with chronic sarcoidosis (n=46). The percentage of “non-eff ector” CD3+CD8+ subsets – “naïve” and central memory – were decreased in comparison with healthy control group (n=46), whereas the relative number of TEMRA cells was signifi cantly increased. Within EM subset percentage of EM1 cells was lower in sarcoidosis group, while among TEMRA the relative number of рЕ2 and mature eff ector cells were increased if compared with healthy control group. Thereby, our results indicate the intensifi cation of CD3+CD8+ lymphocytes maturation in the lymphoid tissue under a constant antigenic stimulation.
作者简介
N. Lazareva
Academician I.P. Pavlov First St. Petersburg State Medical University; State Research Institute of Highly Pure Biopreparations
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I. Kudryavtsev
Academician I.P. Pavlov First St. Petersburg State Medical University; Institute of Experimental Medicine
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O. Baranova
Academician I.P. Pavlov First St. Petersburg State Medical University
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M. Serebriakova
Institute of Experimental Medicine
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T. Ses’
Academician I.P. Pavlov First St. Petersburg State Medical University; State Research Institute of Highly Pure Biopreparations
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M. Ilkovich
Academician I.P. Pavlov First St. Petersburg State Medical University
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A. Totolyan
Academician I.P. Pavlov First St. Petersburg State Medical University; St. Petersburg Pasteur Institute
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参考
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