Experimental justification of the possibility of creating the new metabolic drug

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This scientifi c work is devoted to the study of the possibility of creating a new metabolic drug (using biologically active substances of the probiotic strain Bacillus subtilis B-3679) for use as a preventive and therapeutic agent for infl ammatory diseases of tissues and organs of the oral cavity. Previously, the metabolites of spore probiotic microorganisms were practically not used for the design of medical pharmacological preparations.

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N. Zabokritsky

Federal State Budgetary Scientifi c Institution Research Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

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Email: noemail@neicon.ru
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P. Sarapultsev

Federal State Budgetary Scientifi c Institution Research Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Email: noemail@neicon.ru
俄罗斯联邦

参考

  1. Забокрицкий Н. А. Экспериментальная оценка коррекции гуморального иммунитета гепатопротекторным препаратом гепатобиол у лабораторных животных с острым токсическим гепатитом. Российский иммунологический журнал, 2017, 11, 2(20), 123–126. [Zabokritskiy N. A. Experimental estimation of correction of humoral immunity hepatoprotective drug hepatobiol in laboratory animals C acute toxic hepatitis, 2017, 11, 2(20), 123–126].
  2. Забокрицкий Н. А. Оценка иммунотропного действия пробиотика бацилакт в составе трансдермальных терапевтических систем. Российский иммунологический журнал, 2017, 11, 2(20), 126–129. [Zabokritskiy N. A. Preclinical evaluation of immunotropic action of probiotics bacilack transdermal therapeutic system, 2017, 11, 2(20), 126–129].
  3. Забокрицкий Н. А. Обоснование направлений в разработке и экспериментальном изучении новых фармакологических препаратов на основе пробиотиков и их биологически активных продуктов: автореф. дис. … д-ра. мед. наук., 2014. 3–16. [Zabokritskiy N. A. Study areas in the development and experimental study of new pharmacological products based on probiotics and their bioactive products: abstract of dis. … dr. med. sciences, 2014. 3–16].
  4. Лабинская А. С. Микробиология с техникой микробиологических исследований. Бином, М., 2012. 72–124. [Labinskaya А. S. Microbiology with technique of microbiological studies.: Binom, Moscow, 2012. 72–124].
  5. Holzapfel W. H., Schillinger U. Introduction to preand probiotics. Food Research International 35, 2002, 109–116.
  6. Kailasapathy K. A., Chin J. Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifi dobacterium spp. Immunol. Cell. Biol., 2000, 78, 80–88.
  7. Lee Y. K., Salminen S. Handbook of Probiotics and Prebiotics. John Wiley and Sons, Ltd., 2009, 132–144.
  8. Russel J., Cohn R.,Probiotics. U.K., Edinburgh: LENNEX Corp. 2012, 5–58.

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