Impact of subcutaneus allergenspecifi c immunotherapy on the level of cytokines in nazal secretions of children with combined forms of respiratory pollene allergy

In children with concomitant respiratory forms of pollen allergy after three courses of the subcutaneous immunotherapy in nasal secretions investigated levels of G-CSF, GM–CSF, IL-10, IL-12p70, INF-gamma, IL-13, IL-17A, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, TNF-alpha, IL-8, MCP-1, MIP-1β. Children with combined forms of respiratory allergy to pollen trees in remission of allergic disease at the local epitope (in the nasal mucosa) had signs of chronic infl ammatory process with violation of the immune response by increasing the synthesis of pro- and decreased of production anti-infl ammatory cytokines and gain of reactions aimed at elimination of the allergen. After the subcutaneous immunotherapy showed reduction index IL-1β/INF-¬, IL-1β/IL-4, IL-1β/IL-12 and MIP-1β/IL-12.