The role of mielopeptides MP-5 and MP-6 in regulation of the functional activity of peritoneal macrophages under immobilizational stress
- 作者: Gein S.1,2, Gavrilova T.1, Gein O.3, Kadochnikova Y.2, Chereshneva M.4, Chereshnev V.4, Kirilina E.5
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
- Perm State Medical University
- Perm State Pharmaceutical Academy
- Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
- Institute of Bioorganic Chemistry. M.M. Shemyakin and Yu.A. Ovchinnikov RAS
- 期: 卷 21, 编号 3 (2018)
- 页面: 233-237
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119842
- DOI: https://doi.org/10.31857/S102872210002387-0
- ID: 119842
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详细
The results of the study of the eff ect of MP-5 and MP-6 myelopeptides on the antibody response, production of reactive oxygen species, IL-1β and IL-10 by peritoneal macrophages of mice against a back- ground of 6 hours of immobilization stress in vivo are presented. The stimulating eff ect of MP-5 and MP-6 on the production of reactive oxygen species and IL-1b by peritoneal macrophages was stimulated 6 hours after their administration. Myelopeptides also neutralized the inhibitory eff ect of immobilization stress on zymosan-induced production of reactive oxygen species by peritoneal macrophages and the antibody formation in the spleen.
作者简介
S. Gein
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences; Perm State Medical University
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T. Gavrilova
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
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O. Gein
Perm State Pharmaceutical Academy
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Ya. Kadochnikova
Perm State Medical University
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M. Chereshneva
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
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V. Chereshnev
Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
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E. Kirilina
Institute of Bioorganic Chemistry. M.M. Shemyakin and Yu.A. Ovchinnikov RAS
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参考
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