Antipeptide activity of intestinal microsyмbyonts for the state of intestinal homeostasis estimation
- 作者: Bondarenko T.1, Danilova E.2, Chainikova I.1,2, Chelpachenko O.1, Ivanova E.1, Perunova N.1, Nikiforov I.1
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隶属关系:
- Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
- Orenburg State Medical University
- 期: 卷 21, 编号 3 (2018)
- 页面: 222-226
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119840
- DOI: https://doi.org/10.31857/S102872210002385-8
- ID: 119840
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详细
The paper presents the results of antipeptide activity against pro (TNFα, IFN-γ, IL-6, IL-17) and anti-infl ammatory (IL-10) cytokines of exometabolites of the intestinal microfl ora, isolated in patients with eubiosis, dysbiosis of the large intestine and reactive arthritis. Diff erences in strains of normofl ora and opportunistic microorganisms isolated from various sources, the spectrum of cytokines and the level of their decrease their content in the culture medium were determined upon co-cultivation with exometabolites of the cultures of microorganisms under study. The results obtained can be used to assess the immunoregulatory properties of microfl ora in various microecological conditions of the human colon and in extraintestinal infl ammatory pathology.
作者简介
T. Bondarenko
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
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E. Danilova
Orenburg State Medical University
Email: noemail@neicon.ru
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I. Chainikova
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS; Orenburg State Medical University
Email: noemail@neicon.ru
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O. Chelpachenko
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Email: noemail@neicon.ru
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E. Ivanova
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Email: noemail@neicon.ru
俄罗斯联邦
N. Perunova
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Email: noemail@neicon.ru
俄罗斯联邦
I. Nikiforov
Institute for Cellular and Intracellular Symbiosis of Ural Branch of RAS
Email: noemail@neicon.ru
俄罗斯联邦
参考
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