Peculiarities of the exposure of the antibiotics of the macrolid group on the functional activity of neutrophilic granulocytes of peripheral blood in vitro
- 作者: Baturina I.1, Savochkina A.1, Gromakova K.1,2, Nikushkina K.1, Emelyanov I.1,2, Zotova M.1, Mezentseva E.1
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隶属关系:
- South Ural State Medical University
- Chelyabinsk State University
- 期: 卷 21, 编号 3 (2018)
- 页面: 216-221
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119839
- DOI: https://doi.org/10.31857/S102872210002384-7
- ID: 119839
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详细
Dose-dependent eff ects of antibiotics and their eff ect on immune cells of the body, in particular neu-trophilic granulocytes, are still poorly understood. The method of fl ow cytometry was determined by the minimum eff ective dose of chemomycin by assessing the degranulation of neutrophils. It was found that under the action of minimum eff ective dose chemomycin neutrophils form neutrophil extracellular traps (NETs), which are one of the mechanisms of adaptive immunity. It is noteworthy that the release of NETs in response to the action of chemomycin was not dependent on gender.
作者简介
I. Baturina
South Ural State Medical University
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Email: noemail@neicon.ru
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A. Savochkina
South Ural State Medical University
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K. Gromakova
South Ural State Medical University; Chelyabinsk State University
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K. Nikushkina
South Ural State Medical University
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I. Emelyanov
South Ural State Medical University; Chelyabinsk State University
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M. Zotova
South Ural State Medical University
Email: noemail@neicon.ru
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E. Mezentseva
South Ural State Medical University
Email: noemail@neicon.ru
俄罗斯联邦
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