METABOLIC REPROGRAMMING OF MACROPHAGES ACTIVATED BY A NOD1 RECEPTOR AGONIST

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We provide the fi rst characterization of glucose and energy metabolism rearrangements in human macrophages upon their activation with a NOD1 receptor agonist (N-acetyl-D-muramyl-L-alanylD-isoglutamyl-meso-diaminopimelic acid, or M-triDAP) in comparison with the eff ects of a TLR4 agonist, lipopolysaccharide (LPS). We demonstrate possibilities of modulation of cytokine production by macrophages using glycolysis inhibitors.

作者简介

M. Pashenkov

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

编辑信件的主要联系方式.
Email: mvpashenkov@yandex.ru

Doctor of medical sciences, Acting head of the Laboratory of Clinical Immunology,

Moscow

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N. Murugina

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

junior researcher, Laboratory of Clinical Immunology,

Moscow

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A. Budikhina

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

PhD, researcher, Laboratory of Clinical Immunology,

Moscow

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P. Maximchik

Lomonosov Moscow State University

Email: fake@neicon.ru

PhD, researcher, Faculty of Fundamental Medicine, 

 

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Y. Dagil

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

researcher, Laboratory of Clinical Immunology,

Moscow

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L. Balyasova

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

junior researcher, Laboratory of Clinical Immunology,

Moscow

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V. Murugin

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

PhD, researcher, Laboratory of Clinical Immunology,

Moscow

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G. Chkadua

FSBI “N. N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation

Email: fake@neicon.ru

PhD, senior researcher, Laboratory of experimental diagnostics and biotherapy of tumors,

Moscow

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B. Pinegin

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Email: fake@neicon.ru

Professor, Doctor of medical sciences, Head of the Department of immunodiagnostics and immunocorrection,

Moscow

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参考

  1. O’Neill L. A., Pearce E. J. Immunometabolism governs dendritic cell and ma.crophage function. J Exp Med 2015, 213, 15–23.
  2. Jha A. K., Huang S. C., Sergushichev A., Lampropoulou V., Ivanova Y., Loginicheva E., Chmielewski K., Stewart K. M., Ashall J., Everts B., Pearce E. J., Driggers E. M., Artyomov M. N. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity 2015, 42 (3), 419–430.

版权所有 © Pashenkov M.V., Murugina N.E., Budikhina A.S., Maximchik P.V., Dagil Y.A., Balyasova L.S., Murugin V.V., Chkadua G.Z., Pinegin B.V., 2019

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