IMMUNE ASPECTS OF CANCER DEVELOPMENT

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Local and systemic immune responses are involved in the development of the malignant tumor at all stages of the process, from the appearance of transformed cellsto the clinical progression of the disease. The review includes the main provision of the modern concepts of oncogenesis, antitumor immune surveillance, immunoediting and the role of tumor-promoting chronic infl ammation.

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T. Karmakova

P. A. Hertsen Moscow Oncology Research Institute – the branch of National Medical Research Radiological Center

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Email: kalmar123@yandex.ru

PhD, Leading Researcher, Department of Modifi ers and Protective Agents for Anticancer therapy,

Moscow

俄罗斯联邦

参考

  1. Hanahan D., Weinberg R. A. Hallmarks of cancer: the next generation. Cell. 2011, 144(5), 646–674.
  2. Gonzalez H., Hagerling C., Werb Z. Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev. 2018, 32, 1267–1284.
  3. Mittal D., Gubin M. M., Schreiber R. D., Smyth M. J. New insights into cancer immunoediting and its three component phases – elimination, equilibrium and escape. Curr Opin Immunol. 2014, 27, 16–25.
  4. Bottazzi B., Riboli E., Mantovani A. Aging, inflammation and cancer. SeminImmunol. 2018, 40, 74–82.
  5. D’Errico G., Machado H. L., Sainz B. Jr. A current perspective on cancer immune therapy: step-by-step approach to constructing the magic bullet. Clin Trans Med. 2017, 6, 3
  6. Li Z., Song W., Rubinstein M., Liu D. Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing. J Hematol Oncol. 2018, 11, 142.

版权所有 © Karmakova T.A., 2019

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