EXPERIMENTAL MODEL FOR THE STUDY OF A INDEPENDENT FROM THE LYMPHOCYTES OF POLARIZATION INTESTINAL MACROPHAGES IN THE MICE
- 作者: Litvinova E.A.1,2, Achasova K.M.2,1
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隶属关系:
- Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences
- The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 852-854
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119755
- DOI: https://doi.org/10.31857/S102872210006651-1
- ID: 119755
如何引用文章
全文:
详细
Acute inflammatory begins to activate of M1-macrophage by classical pathway. In the chronic form of the disease, the body triggers an adaptive alternative pathway to activate of M2-macrophages. For example, the number of intestinal M2-macrophages increases in infl ammatory bowel disease (IBD) of a chronic form. We have got a model of mice that do not have mature lymphocytes and these animals development of IBD due to the absence of a intestinal mucosal barrier. We obtained a good model that reveals the role of macrophages and lymphocytes in the development of IBD, and can also be used to understand the effect of pharmacological drugs that cause polarization of macrophages.
作者简介
E. Litvinova
Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences;The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: dimkit@mail.ru
leading researcher in the laboratory for regulation of agricultural animals and plants microbiocenosis;
senior researcher in the laboratory of genetics of laboratory animals,
Novosibirsk
俄罗斯联邦K. Achasova
The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences;Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences
Email: fake@neicon.ru
PhD student in the laboratory of genetics of laboratory animals;
junior researcher in the laboratory for regulation of agricultural animals and plants microbiocenosis,
Novosibirsk
俄罗斯联邦参考
- Martinez F. O., Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. // F1000Prime Rep. – 2014. – V.6. – P. 13. doi: 10.12703/P6–13.
- Goswami K. K., Sarkar M., Ghosh S., Saha A., Ghosh T., Guha I., Barik S., Banerjee S., Roy S., Bose A., Dasgupta P., Baral R. Neem leaf glycoprotein regulates function of tumor associated M2 macrophages in hypoxic tumor core: Critical role of IL-10/STAT3 signaling. // Molecular Immunology. –2016. – V.80. – P. 1–10.doi: 10.1016/j.molimm.2016.10.008.
- Mills C. D., Ley K. J. M1 and M2 macrophages: the chicken and the egg of immunity. // Innate Immun. – 2014. – V6(6). – P. 716–726. doi: 10.1159/000364945.
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