THE ROLE OF MACROPHAGES IN REGENERATION OF MUSCLE TISSUE INDUCED BY ALLOGENIC BIOMATERIAL
- 作者: Lebedeva A.1,2, Muslimov S.1,2, Afanasiev S.3, Kondratieva D.3
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隶属关系:
- Federal State Budgetary Institution «The Russian Eye and Plastic Surgery Centre» of the Russian Federation Health Ministry
- Federal State Budgetary Education Institution «Bashkir State Medical University» of the Russian Federation Health Ministry
- Federal State Budgetary Research Institute of Cardiology, Tomsk National Research Medical Centre
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 849-851
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119747
- DOI: https://doi.org/10.31857/S102872210006676-8
- ID: 119747
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全文:
详细
Allogeneic biomaterials (AB) after implantation in a defect in the calf muscles of rats and the uterine horn of the rat contribute to the regeneration of tissues due to migration of M1 macrophages expressing Pro-inflammatory factors, TNFα, IL-1. They inhibit the migration of M2 macrophages, fibrosis factors, promote migration and differentiation of myocytes. IN ischemic damaged myocardium after AB implantation, on the contrary, cd68 macrophage deficiency was found, but high expression by Timp2 cells compared to the control, which could contribute to the reduction of scar area. After the introduction of AB in muscle tissues revealed resident macrophages with phenotype IL-1+/CD68+/PCNA+/Hale+/ vimentin+/FGF1- /TGF-β1–.
作者简介
A. Lebedeva
Federal State Budgetary Institution «The Russian Eye and Plastic Surgery Centre» of the Russian Federation Health Ministry;Federal State Budgetary Education Institution «Bashkir State Medical University» of the Russian Federation Health Ministry
编辑信件的主要联系方式.
Email: jeol02@mail.ru
BD, PhD, senior research assistant of the Department of morphology,
Ufa
俄罗斯联邦S. Muslimov
Federal State Budgetary Institution «The Russian Eye and Plastic Surgery Centre» of the Russian Federation Health Ministry;Federal State Budgetary Education Institution «Bashkir State Medical University» of the Russian Federation Health Ministry
Email: fake@neicon.ru
MD, PhD, Prof.,
Ufa
俄罗斯联邦S. Afanasiev
Federal State Budgetary Research Institute of Cardiology, Tomsk National Research Medical Centre
Email: fake@neicon.ru
MD, PhD, Prof.,
Tomsk
俄罗斯联邦D. Kondratieva
Federal State Budgetary Research Institute of Cardiology, Tomsk National Research Medical Centre
Email: fake@neicon.ru
PhD in Biology, research associate,
Tomsk
俄罗斯联邦参考
- Muldashev E. R., Muslimov S. A., Musina L. A., Nigmatullin R. T., Lebedeva A. I., Shangina O. R., Khasanov R. A. The role of macrophages in the tissues regeneration stimulated by the biomaterials. Cell Tissue Bank. 2005; 6(2): 99–107.
- Lavine K. J., Epelman S., Uchida K., Weber K. J., Nichols C. G., Schilling J. D., Ornitz D. M., Randolph G. J., Mann D. L. Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. PNAS. 2014. 111 (45):16029–16034.
