THE CONDITION OF SYSTEMIC IMMUNITY IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS AND HUMAN PAPILLOMA VIRUS

Genital endometriosis is an estrogen-dependent inflammatory disease, the etiology of which is not known. Given the high prevalence of HPV among women of reproductive age, as well as the development of endometriosis mainly in the same age group, we can assume the participation of HPV in the formation of features of systemic immunity in this disease. The results of the study showed the presence of HPV in 13 (18,8%) women with 1–2 stages of endometriosis and in 22 (24,4%) – with 3–4 stages of endometriosis. In the presence of HPV in women with 1–2 stages of endometriosis, it was established: an increase in the relative number of T-NK lymphocytes, a decrease in IL-2, IL-6 and an increase in serum IL-4, TNFα, IFNγ. With 3–4 stages – an increase in the absolute number of T-NK-lymphocytes, IL-4, IL-8, IL-10, TNFα, IFNγ in serum. Thus, in women with endometriosis in the presence of HPV, the features of systemic immunity have been identified, which may be associated with disease progression.