TREATMENT-AND-PROPHYLACTIC EFFICIENCY OF SYNTHETIC PEPTIDE OF GLUTAMIL-TRYPTOPHANE AT THE VISCERAL PATHOLOGY CAUSED BY A HEAVY MECHANICAL POLYTRAUMA

The efficacy and safety of using synthetic dipeptide alpha-glutamyl-tryptophan in the complex therapy of severe mechanical polytrauma of various nature were investigated. The trial included 327 people. Patients were randomly assigned to two groups: experimental and control (160 and 167 people, respectively). Both groups received standard combination therapy, but the experimental group received additionally the immunotropic drug "Timogen^®" (alpha-glutamyl-tryptophan). The drug was administered intramuscularly in a daily dose of 100 mcg during 10-day course not later than 24 hours after traumatic injuries. The structure, the severity and the progress of the visceral pathology, as well as dynamics of the immune system were evaluated in the comparative groups. "Timogen^®" facilitates reduction of the incidence of visceral complications, and if they develop, it decreases duration of the main clinical manifestations normalizing the structural, quantitative and functional parameters of the immune system and accelerating regeneration of damaged tissues in patients with severe mechanical polytrauma.

глутамил-триптофан, висцеральная патология, политравма, glutamyl-tryptophan, polytrauma, visceral pathology