EFFECT OF PREGNANCY-SPECIFIC β1-GLYCOPROTEIN ON THE DIFFERENTIATION AND PROLIFERATION OF TH17-POLARIZED HELPER T CELLS

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The effect of the native (non-recombinant) pregnancy specific β1-glycoprotein (PSG) preparation on the differentiation and proliferation of Th-17 polarized helper T cells was studied. The object of the study was the culture of “naive” helper T cells (CD4+) isolated by the immunomagnetic separation. Cells were polarized into the Th17 phenotype using TCR-activator and pro-inflammatory cytokines (IL-1β and IL-6). It was shown that PSG had a suppressive effect on the Th17 cell frequency in culture (CD4+ROR-γt+), and inhibited the proliferation of these cells, as measured by the method of differential gating. Thus, in the experimental model used, PSG had a pronounced suppressive effect on the differentiation and proliferation of T-helpers polarized into the Th17 phenotype.

作者简介

V. Timganova

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

编辑信件的主要联系方式.
Email: timganovavp@gmail.com

Ph.D. (Biology), junior researcher, laboratory of ecological immunology,

Perm

俄罗斯联邦

M. Bochkova

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Ph.D. (Biology), researcher, laboratory of ecological immunology,

Perm

俄罗斯联邦

A. Kalugina

Perm State University

Email: fake@neicon.ru

student of the department of microbiology and immunology,

Perm

俄罗斯联邦

P. Khramtsov

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»;
Perm State University

Email: fake@neicon.ru

Ph.D. (Biology), researcher, laboratory of ecological immunology;

assistant professor of the department of microbiology and immunology, Faculty of Biology,

Perm

俄罗斯联邦

M. Raev

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»;
Perm State University

Email: fake@neicon.ru

Ph.D., MD (Biology), Leading Researcher, Laboratory of Ecological Immunology;

professor of the department of microbiology and immunology, Faculty of Biology,

Perm

俄罗斯联邦

S. Zamorina

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»;
Perm State University

Email: fake@neicon.ru

Ph.D., MD (Biology), leading researcher, laboratory of ecological immunology;

professor of the department of microbiology and immunology, Faculty of Biology,

Perm

俄罗斯联邦

参考

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版权所有 © Timganova V.P., Bochkova M.S., Kalugina A.P., Khramtsov P.V., Raev M.B., Zamorina S.A., 2019

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