PREDICTOR SIGNIFICANCE OF POLYMORPHISMS OF INTERFERON GAMMA AND INTERLEUKIN4 GENES IN CHILDREN IN BRONCHIAL ASTHMA

At present, in spite of a considerable number of studies, the questions of studying the polymorphisms of genes associated with the regulation of immune homeostasis in allergic diseases remain relevant. The aim of the work included the analysis of the frequency of occurrence of variations in the interferongamma and interleukin-4 genotypes in children with asthma and healthy peers. As a result of the study, a signifi cant prevalence of the heterozygous variant of the IL-4 gene was found in the group of healthy children and the peer group with BA, the haplotype CC prevails in healthy peers. When analyzing the genetic variation of the IFNγ gene, a protective eff ect was revealed in the haplotype of TT and the heterozygous variant of AT in relation to the risk of developing bronchial asthma. The results of the study allow us to recommend haplotype TT as a protective marker for the development of allergic BA. The studies established the predictor signifi cance of polymorphisms of the IFNγ and IL-4 genes in children with bronchial asthma.