REACTION OF ACTIVATED MONONUCLEATED CELLS TO CO-CULTIVATION WITH CALCIUM PHOSPHATE COATING OF TITANIUM MATRIX


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The reactions of mononuclear blood cells (MNC) were evaluated under cocultivation with titanium substrates carrying a bilateral calcium phosphate coating (CP) under conditions of additional activation of the T-cell receptor. It has been established that in the activation 3D model, in contact with CP-coating, the secretion of pro- and anti-inflammatory cytokines (IL-2, TNF-α, IL-10, IL-4) increases, against the background of a decrease in the viability of the MNC culture and changes in their immunophenotype, in the direction of increasing the number of cells expressing CD95+ and CD45R0+ (the number of CD25+ cells has not changed), which may indicate that the MNC is hyperactive in the 3D model when it is stimulated by an activator of T cells.

作者简介

L. Litvinova

Immanuel Kant Baltic Federal University

编辑信件的主要联系方式.
Email: fake@neicon.ru

MD, Head of the Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

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K. Yurova

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Ph.D., Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

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V. Shupletsova

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Ph.D. Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

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O. Khaziakhmatova

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Ph.D., Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

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E. Melashchenko

Immanuel Kant Baltic Federal University

Email: lena.melashchenko17@mail.ru

Biologist of the Center for Medical Biotechnology,

Kaliningrad

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V. Malashchenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Researcher, Center for Medical Biotechnologies,

Kaliningrad

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E. Shunkin

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Engineer Researcher Basic Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

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Yu. Sharkeev

Tomsk Polytechnic University

Email: fake@neicon.ru

Doctor of Physics and Mathematics, Professor, Head. lab Physics of nanostructured biocomposites,

Tomsk

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E. Komarova

Tomsk Polytechnic University

Email: fake@neicon.ru

Ph.D., Junior Researcher, Laboratory of Physics of Nanostructured Biocomposites,

Tomsk

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M. Sedelnikova

Tomsk Polytechnic University

Email: fake@neicon.ru

Doctor of Technical Sciences Senior Researcher, Laboratory of Physics of Nanostructured Biocomposites,

Tomsk

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I. Norkin

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

PhD student,

Kaliningrad

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K. Prokin

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

student,

Kaliningrad

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P. Ivanov

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

Researcher at the Base Laboratory of Immunology and Cell Biotechnology,

Kaliningrad

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I. Khlusov

Siberian State Medical University;
Tomsk Polytechnic University

Email: fake@neicon.ru

Ph.D. Professor of the Department of Morphology and General Pathology;

Professor of the Research School of Chemical and Biomedical Technologies,

Tomsk

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参考

  1. Baht G. S., Vi L., Alman B. A. The Role of the Immune Cells in Fracture Healing. Curr Osteoporos Rep. 2018;16(2):138–145.

版权所有 © Litvinova L.S., Yurova K.A., Shupletsova V.V., Khaziakhmatova O.G., Melashchenko E.S., Malashchenko V.V., Shunkin E.O., Sharkeev Y.P., Komarova E.G., Sedelnikova M.B., Norkin I.K., Prokin K.I., Ivanov P.A., Khlusov I.A., 2019

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