COEXPRESSION OF IMMUNE CHECKPOINT MARKERS PD-1, PD-L1, TIM-3, AND LAG-3 IN CIRCULATING AND TUMOR-INFILTRATING T CELL POPULATIONS IN CERVICAL CANCER PATIENTS


如何引用文章

全文:

详细

The article presents the results of immunophenotyping performed on T cells from early-stage cervical cancer patients using immune checkpoint markers considered as promising and valid targets for antitumor immunotherapy. The differences in the expression pattern of these markers between lymphocyte subpopulations isolated from the tumor site or peripheral blood are discussed.

作者简介

O. Kurmyshkina

Petrozavodsk State University

编辑信件的主要联系方式.
Email: fake@neicon.ru

PhD, seniorresearcher, Laboratory of Molecular Genetics of Innate Immunity, Institute of High-Tech Biomedicine,

Petrozavodsk

俄罗斯联邦

A. Bogdanova

Petrozavodsk State University;
Institute of Biology of the Karelian Research Centre of the RAS

Email: fake@neicon.ru

PhD student, Laboratory for Environmental Biochemistry,

Petrozavodsk

俄罗斯联邦

P. Kovchur

Petrozavodsk State University

Email: fake@neicon.ru

MD-PhD, professor of the Department of hospital surgery, ENT diseases, ophthalmology, dentistry, oncology, urology, Institute of Medicine,

Petrozavodsk

俄罗斯联邦

T. Volkova

Petrozavodsk State University

Email: VolkovaTO@yandex.ru

PhD, professor of the Department ofbiomedical chemistry, immunology and laboratory diagnostics, Institute of Medicine; director of the Institute of High-Tech Biomedicine,

Petrozavodsk

俄罗斯联邦

参考

  1. Wang HF, Wang SS, Tang YJ, Chen Y, Zheng M, Tang YL, Liang XH. The Double-Edged Sword-How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer.Front Immunol. 2019, 10, 653.
  2. Liu Y, Wu L, Tong R, Yang F, Yin L, Li M, You L, Xue J, Lu Y. PD-1/PD-L1 Inhibitors in Cervical Cancer.Front Pharmacol. 2019, 10, 65.
  3. Heeren AM, Rotman J, Stam AGM, Pocorni N, Gassama AA, Samuels S, Bleeker MCG, Mom CH, Zij lmans HJMAA, Kenter GG, Jordanova ES, de Gruij l TD. Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels. J Immunother Cancer. 2019, 7, 43.

版权所有 © Kurmyshkina O.V., Bogdanova A.A., Kovchur P.I., Volkova T.O., 2019

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可
##common.cookie##