THYMUS IN AUTOIMMUNE DISEASES CLINIC. THE ACTUALITY AND PROSPECTIVES OF “IN VIVO” MONITORING
- 作者: Goloviznin M.1, Lakhonina N.1, Timofeev V.2, Buldakova Y.1
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隶属关系:
- A.I Evdokimov Moscow State University of Medicine and Dentistry
- N.I.Pirogov Russian Scientifi c-Research State Medical University
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 208-211
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119580
- DOI: https://doi.org/10.31857/S102872210006460-1
- ID: 119580
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全文:
详细
The leading role of Thymus in adoptive immunity development was established 50 years ago. Nevertheless T-cells immunity monitoring in clinical immunology is now testing of growing number of “immune periphery” items disregarding thymus as a central T-immunity organ. We showed that T-cells rearrangement excision circles (TREC) could be the important chain in thymus and peripheral T-cells function assessment in adult and aged healthy donors and rheumatoid arthritis patients. It will create the possibility to form more complex “in vivo” monitoring of thymus activity in autoimmunity.
作者简介
M. Goloviznin
A.I Evdokimov Moscow State University of Medicine and Dentistry
编辑信件的主要联系方式.
Email: ordinatormgmsu@mail.ru
PhD, Associate professor of the Department of Internal Diseases of dental faculty,
Moscow
俄罗斯联邦N. Lakhonina
A.I Evdokimov Moscow State University of Medicine and Dentistry
Email: fake@neicon.ru
Assistant professor of the Department of Internal Diseases of dental faculty,
Moscow
俄罗斯联邦V. Timofeev
N.I.Pirogov Russian Scientifi c-Research State Medical University
Email: fake@neicon.ru
D. Sci, Leading researcher of Faculty therapy department,
Moscow
俄罗斯联邦Yu. Buldakova
A.I Evdokimov Moscow State University of Medicine and Dentistry
Email: fake@neicon.ru
PhD, Associate professor of the Department of Internal Diseases of dental faculty,
Moscow
俄罗斯联邦参考
- Хайдуков С. В. Малые субпопуляции Т-хелперов (Th наивные тимические, Th наивные центральные, Th9, Th22 и CD4+CD8+ дважды положительные Т-клетки) // Медицинская иммунология. – 2013. – том 15, № 6 – С. 503–512.
- Донецкова А. Д., Ярилин А. А. T-рецепторные эксцизионные кольца и значимость их определения в клинике // Иммунология. – 2013. – № 4. – С. 220– 226.
- Ярилин А. А. Основы иммунологии. – Москва: «Медицина», 1999 г. – 608 с.
