PSYCHONEUROIMMUNOMODULATORY EFFECTS OF THE ORIGINAL ANTICONVULSANT AT EXPERIMENTAL ALCOHOLISM

封面

如何引用文章

全文:

详细

An essential link in the pathogenesis of alcohol dependence is a violation of the mechanisms of neuroimmune interaction, which determines the prospect of finding new effective and safe pharmacological correction tools that act on the molecular targets of the ethanol infl uence in the central nervous system and can correct neuroimmune dysregulation. A positive psychoneuroimmunomodulating effect was demonstrated in the experimental alcohol dependence of the original anticonvulsant, which has a modulating effect on the GABA / benzodiazepine receptor complex. The effect was expressed in the reduction of pathological craving for alcohol, stimulation of parameters of exploratory behavior and immune response, which makes the use of anticonvulsant in the therapy of chronic alcoholism promising and can provide a new pharmacotherapeutic approach to the prevention and treatment of this disease.

作者简介

E. Markova

Federal State Budgetary Scientific Research Institute of the fundamental and clinical immunology;
Federal State Budgetary Educational Institution of Higher Education “Novosibirsk
State Pedagogical University»

编辑信件的主要联系方式.
Email: evgeniya_markova@mail.ru

MD, head of the Neuroimmunology laboratory, chief researcher;

Professor,

Novosibirsk

俄罗斯联邦

I. Savkin

Federal State Budgetary Scientific Research Institute of the fundamental and clinical immunology

Email: fake@neicon.ru

researcher of the Neuroimmunology laboratory,

Novosibirsk

俄罗斯联邦

M. Knyazheva

Federal State Budgetary Scientific Research Institute of the fundamental and clinical immunology

Email: fake@neicon.ru

postgraduate student of the Neuroimmunology laboratory,

Novosibirsk

俄罗斯联邦

T. Shushpanova

Mental Health Research Institute“Tomsk Scientific Research Medical Center of Russian Academy of Sciences”

Email: fake@neicon.ru

PhD, lleading researcher, laboratory of clinical psychoneuroimmunology and neurobiology,

Tomsk

俄罗斯联邦

T. Novozheeva

Mental Health Research Institute“Tomsk Scientific Research Medical Center of Russian Academy of Sciences”

Email: fake@neicon.ru

BD, senior researcher, Laboratory of clinical psychoneuroimmunology and neurobiology,

Tomsk

俄罗斯联邦

参考

  1. Крыжановский Г. Н., Асмаев И. Г., Магаев С. В., Морозов С. Г. Нейроиммуноэндокринные взаимодействия в норме и патологии. М.: Медицинская книга. 2010, 288.
  2. Cui C., Grandison L., Noronha A. Neuroimmune mechanisms of brain function and alcohol related disorders. Brain, Behavior, and Immunity 2011, 25, 1–3.
  3. Kelleya K. W., R. Dantzer. Alcoholism and inflammation: Neuroimmunology of behavioral and mood disorders. Brain, Behavior, and Immunity 2011, 25 (1), 13–20.
  4. Чухрова М. Г., Дресвянников В. Л., Маркова Е. В. Наркотическая зависимость: современные стратегии исследования. Saint-Louis, Missouri, USA. 2015.
  5. Centanni S. W., Teppen T., Risher M. L., Fleming R. L., Moss J. L., Acheson S. K., et al. Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus. Alcohol. Clin.Exp. Res. 2014, 38, 2800–2808.
  6. Follesa P., Floris G., Asuni G. et al. Chronic Intermittent Ethanol Regulates Hippocampal GABA(A) Receptor Delta Subunit Gene Expression. Front. Cell. Neurosci. 2015, 9, 445.
  7. Follesa P., Biggio F., Caria S., Gorini G., Biggio G. Modulation of GABA(A) receptor gene expression by allopregnanolone and ethanol. Eur. J. Pharmacol. 2004, 500, 413–425.
  8. Collingridge G. L., lsaac J. T., Wang У. Т. Receptor trafficking and synaptic plasticity. Nature Reviews. Neumscience. 2004, 5, 952–962.
  9. Shushpanova Т. V., Bokhan N. А., Lebedeva Y. F., Solonskii А. V., Udut V. V. The effect of chronic alcohol abuses оп the benzodiazepine receptor system in various areas of the human brain. African J Psychiary 2016, 19 (3), 1000365 doi: 10.4172/2378-5756.1000365
  10. Анохина И. Л. Основные биологические механизмы зависимости от психоактивных веществ. Наркология: национальное руководство / под ред. Н. Н. Иванца, И. Л. Анохиной, М. А. Винниковой. М.: ГЭОТАР-Медиа. 2008.
  11. Novozheeva T., Markova E., Shushpanova O., Knyazeva E., Shushpanova T. Optimizing pharmacotherapy of epilepsy by creating new ways of administering of original anticonvulsant meta-chlorobenzhydryl urea (m-CLBHU). European psychiatry 2019, 56, S15.
  12. Буреш Я., Бурешова О., Хьюстон Д. П. Методики и основные эксперименты по изучению мозга и поведения. М; 1991. 399.
  13. Cunningham A. J. A method of increased sensitivity for detecting single antibody-forming cells. Nature 1965, 207, 1106–1107.
  14. Yoshikai Y., Miake S., Matsumoto T., et al. Effect of stimulation and blockade of mononuclear phagocyte system on the delayed footpad reaction to SRBC in mice. Immunol. 1979, 38, 3, 577–583.
  15. Гольдина И. А., Маркова Е. В., Гольдин Б. Г., Княжева М. А., Гайдуль К. В. Протекторные свойства экстракта куркумы при этанолиндуцированных нарушениях поведения Саратовский научномедицинский журнал 2017, 13, 1, 131–135.
  16. Маркова Е. В. Иммунная система и высшая нервная деятельность. Механизмы нейроиммунных взаимодействий в реализации и регуляции поведенческих реакций. Saarbruken. 2012.
  17. Cavalotti D., Artico M., D`Andrea V., Cavalotti C. GABA-transaminase activity in the human thymus after administration of interferons. Hum. Immunol. 2000, 61, 697–704.
  18. Geigerseder C., Doepner R., Thalhammer A., Frungieri M. B., Gamer-Dimelon K., Calandra R. S., Kohn F. M., Maverhofer A. Evidence for a GABAergic system I rodent and human testis; local GABA production and GABA receptors. Neuroendocrinology 2003, 77, 314–28.
  19. Alam S., Laughton D. L., Walding A., Wolstenholme A. J. Human peripheral blood mononuclear cells express GABAA receptor subunits. Mol Immunol. 2006, 43, 9, 1432–1442.
  20. Mendu S. K., Akesson L., Jin Z., et al. Increased GABAA channel subunits expression in CD8+ but not in CD4+ T cells in BB rats developing diabetes compared to their congenic littermates. Molecular immunology. 2011, 48, 4, 399–407.
  21. Tian J., Chau C., Hales T. G., Kaufman D. L. GABA receptors mediate inhibition of T-cell responses. J. Neuroimmunol. 1999, 1, 21–28.
  22. Bandyopadyay B. C., Poddar М. Hypocampic GABAergic activity and T-cell proliferation in aged mammal; effect of dietary protein. Neurochem. Int. 1998, 32, 191–196.
  23. Idova G., Alperina E. L., Cheido M. A. Contribution of brain dopamine, serotonin and opioid receptors in the mechanisms of neuroimmunomodulation: evidence from pharmacological analysis. Inter. Immunopharmacol. 2012, 12, 4, 618–625.
  24. Lingford-Hughes A. R., Watson B., Kalk N., Reid A. Neuropharmacology of addiction and how it informs treatment. Br. Med. Bull. 2010, 96, 93–110.
  25. Савкин И. В., Маркова Е. В., Шушпанова Т. В., Новожеева Т. П., Козлов В. А. Влияние антиконвульсанта галодиф на алкогольную мотивацию, рецепторные системы и цитокины в мозге в эксперименте. Российский иммунологический журнал 2018, 12 (21), 733–735.
  26. Shushpanova T., Novozheeva T., Solonskii A., Bokhan N., Markova E. Molecular targets of the ethanol and original anticonvulsant in the treatment of alcohol dependence. European Psychiatry 2017, 41(S), 350.

版权所有 © Markova E.V., Savkin I.V., Knyazheva M.A., Shushpanova T.V., Novozheeva T.P., 2019

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可
##common.cookie##