RELATIONSHIP CHARACTER OF COLLAGEN SYNTHESIS IN UTERINE LEIOMYOMA TISSUE WITH FEATURES OF TUMOR GROWTH

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The aim of the work was to elucidate the features of collagen 1A1 mRNA expression in uterine leiomyoma. It was found that the high level of collagen synthesis is associated with rapidly increase of leiomyoma size, more frequently noted in small tumors with minimal proliferative activity. Thus, the activity of tissue fi broblasts defi nes the features of tempo and character growth of uterine leiomyoma.

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D. Voskresenskaya

FSBE «Ivanovo’s Research Institute of Maternity and Childhood named after V. N. Gorodkov» of Healthy Ministry of Russian Federation Ivanovo

编辑信件的主要联系方式.
Email: kasyanikdariakis@mail.ru

graduate student of the laboratory of Clinical immunology,

Ivanovo

俄罗斯联邦

A. Malyshkina

FSBE «Ivanovo’s Research Institute of Maternity and Childhood named after V. N. Gorodkov» of Healthy Ministry of Russian Federation

Email: fake@neicon.ru

MD, professor, director,

Ivanovo

俄罗斯联邦

Yu. Antsiferova

FSBE «Ivanovo’s Research Institute of Maternity and Childhood named after V. N. Gorodkov» of Healthy Ministry of Russian Federation

Email: fake@neicon.ru

BD, the leading scientifi c worker of the laboratory of Clinical immunology,

Ivanovo

俄罗斯联邦

参考

  1. Миома матки / под ред. И. С. Сидоровой. – М.: МИА, 2003. – 256 с./ Uterine leiomyoma. Ed I. S. Sidorova. – M.: MIA, 2003. – 256 p.
  2. Иммунные механизмы быстрого роста миомы матки / А. И. Малышкина, Н. Ю. Сотникова, Ю. С. Анциферова, А. К. Красильникова. – Иваново, 2010. –272 с.
  3. Chegini N. Proinflammatory and profibrotic mediators: Principal effectors of leiomyoma development as a fibrotic disorder // Semin Reprod Med. – 2010. – № 28(3). – P. 180–203.

版权所有 © Voskresenskaya D.L., Malyshkina A.I., Antsiferova Y.S., 2019

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