INFLUENCE OF ALPHA-FETOPROTEIN ON CYTOKIN PROFILE OF ACTIVATED T-HELPERS

封面

如何引用文章

全文:

详细

The effect of alpha-fetoprotein (AFP) on the pro-infl ammatory cytokine profi le of activated T-helpers, polarazed in phenotyp of Th17. It was found that AFP did not affect the level of IL-4, IL-5, IL-7, IL-8, IL-10, IL-17, MCP-1, MIP-1α, TNF-α, but in high concentrations (50, 100 IU/ml) increased IL-2 production by activated T-helper cells. At the same time, AFP in high concentration (100 IU/ml) suppressed the synthesis of IFN-γ, and in low (10 IU /ml) synthesis of G-CSF and GM-CSF. Thus, new aspects of the AFP action regarding the regulation of the cytokine network of Th17 are demonstrated.

作者简介

S. Zamorina

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

编辑信件的主要联系方式.
Email: mantissa7@mail.ru

Ph.D., MD (Biology), leading researcher, laboratory of ecological immunology, «Institute of ecology and genetics of microorganisms UB RAS»,

professor of the department of microbiology and immunology of the Perm State University’s Faculty of Biology,

Perm

俄罗斯联邦

L. Litvinova

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

PhD, MD (Medicine), Head, Basic Laboratory of Immunology and Cell Biotechnologies,

Kaliningrad

俄罗斯联邦

N. Todosenko

Immanuel Kant Baltic Federal University

Email: fake@neicon.ru

PhD (Biology), Researcher, Basic Laboratory of Immunology and Cell Biotechnologies, 

Kaliningrad

俄罗斯联邦

V. Timganova

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Ph.D. (Biology), junior researcher, laboratory of ecological immunology,

Perm

俄罗斯联邦

M. Bochkova

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Ph.D. (Biology), researcher, laboratory of ecological immunology,

 

俄罗斯联邦

K. Shardina

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

researcher, laboratory of ecological immunology,

 

俄罗斯联邦

P. Khramtsov

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Ph.D. (Biology), researcher, laboratory of ecological immunology, «Institute of ecology and genetics of microorganisms UB RAS»,

assistant professor of the department of microbiology and immunology of the Perm State University’s Faculty of Biology,

Perm

俄罗斯联邦

M. Raev

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Ph.D., MD (Biology), Leading Researcher, Laboratory of Ecological Immunology, «Institute of ecology and genetics of microorganisms UB RAS»,

professor of the department of microbiology and immunology of the Perm State University’s Faculty of Biology,

Perm

俄罗斯联邦

V. Chereshnev

«Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences»

Email: fake@neicon.ru

Academician of the Russian Academy of Sciences, MD, Chief Researcher,

Perm

俄罗斯联邦

参考

  1. Terentiev A. A., Moldogazieva N. T. Alpha-fetoprotein: A renaissance. Tumor Biol. 2013. V. 34. P. 2075–2091.
  2. González-Bugatto F., Foncubierta E., Bailén Mde L., Illanes S., Hervías-Vivancos B., Bartha J. L. Maternal and fetal serum transformed alpha-fetoprotein levels in normal pregnancy. J. Obstet. Gynaecol. Res. 2009. V. 35(№ 2). P. 271–276.
  3. Schumacher A., Costa S. D., Zenclussen A. C. Endocrine factors modulating immune responses in pregnancy. Front. Immunol. 2014. doi: 10.3389/fimmu.2014.00196
  4. Santner-Nanan B., Peek M. J., Khanam R., Richarts L., Zhu E., Fazekas de St. Groth. B., Nanan R. Systemic increase in the ratio between Foxp3+ and IL-17- producing CD4+ T cells in healthy pregnancy but not in preeclampsia.. J. Immunol. 2009. V. 183, № 11. P. 7023–30.
  5. Saito S., Nakashima A., Shima T., Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am. J. Reprod. Immunol. 2010. V.601, № 63. 601–610.
  6. Xie Q., Wang S. C., Li J. IL-17: a potential therapeutic target for rheumatoid arthritis. Clin Rheumatol. 2012. № 7. Р.1145–6.
  7. Gagnon A., Wilson R. D., Audibert F., Allen V. M., Blight C., Brock J. A., Desilets V. A., Johnson J. A., Langlois S., Summers A., Wyatt P. Obstetrical Complications Associated With Abnormal Maternal Serum Markers Analytes. J. of Obstetrics and Gynaecology Canada. 2008. V. 30. P. 918–932.
  8. Acosta-Rodriguez E.V., Napolitani G., Lanzavecchia A., Sallusto F. Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 2007. V. 8, № 9. P. 942–9.
  9. Ivanov I. I., McKenzie B. S., Zhou L., Tadokoro C. E., Lepelley A., Lafaille J. J., Cua J., Littman D. R. The orphan nuclear receptor ROR γt directs the differentiation program of proinfl ammatory IL-17+ T helper cells. Cell. 2006 V. 126, № 6, P. 1121–1133.
  10. Schumacher A., Brachwitz N., Sohr S., Engeland K., Langwisch S, Dolaptchieva M., Alexander T., Taran A., Malfertheiner S. F., Costa S. D., Zimmermann G., Nitschke C., Volk H. D., Alexander H., Gunzer M., Zenclussen A. C. Human chorionic gonadotropin attracts regulatory T cells into the fetalmaternal interface during early human pregnancy. J Immunol. 2009. V.9. P. 5488–5497.
  11. Figueiredo A. S., Schumacher A. The T helper type 17/ regulatory T cell paradigm in pregnancy. Immunology. 2016 V.148, № 1, P. 13–21. doi: 10.1111/imm.12595.
  12. Paiva P., Hannan N. J., Hincks C., Meehan K. L., Pruysers E., Dimitriadis E., Salamonsen L. A. Human chorionic gonadotrophin regulates FGF2 and other cytokines produced by human endometrial epithelial cells, providing a mechanism for enhancing endometrial receptivity. Hum. Reprod. 2011. V. 11. P. 1153– 1162. doi: 10.1093/humrep/der027

版权所有 © Zamorina S.A., Litvinova L.S., Todosenko N.M., Timganova V.P., Bochkova M.S., Shardina K.Y., Khramtsov P.V., Raev M.B., Chereshnev V.A., 2019

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可
##common.cookie##