ASSESSMENT OF CD127⁻ AND CD95⁺ EXPRESSION AND GENETIC PROFILE OF WOMEN OF REPRODUCTIVE AGE EXPOSED TO PHENOL

The paper presents the results of immunological and genetic blood studies of women of reproductive age living permanently under aerogenic exposure to phenol and having reproductive disorders as recurrent pregnancy loss. Immunological values – expression of T-regulatory CD127 lymphocytes and expression of CD95⁺ lymphocytes involved in apoptosis were studied. The genetic profile of women was analyzed and the polymorphic variants of genes FOXP3 T3499C rs3761547 and FAS C14405T rs1159120 participating in the expression of clusters were determined. It was found out that women having reproductive disorders and living under increased contamination of biological media with phenol have reduced level of expression of T-regulatory cells CD127 relative to healthy and unexposed women, and a lower level of CD95⁺ cells relative to the unexposed women and the norms. It results in malignant course of processes of reproductive disorders (recurrent pregnancy loss).