ASSOCIATIONS OF THE SPECIFIC IMMUNE REACTIONS ON THE CHEMICAL CARCINOGENS AND STEROID HORMONES WITH THE GENE POLYMORPHISMS OF DNA-REPAIR ENZYMES IN BREAST CANCER PATIENTS


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The supposed interrelations of antibodies specific to low-weight xeno- and endobiotics with DNA-repair genes polymorphisms were studied in postmenopausal healthy women (HW) and breast cancer patients (BCP). Enzyme-linked immunoassay was used for IgA and IgG to benzo[a]pyrene, estradiol and progesterone detection in 215 HW and 344 BCP. Gene polymorphisms of XPD/ERCC2 (rs13181), ADPRT/PARP1 (rs1136410), HOGG1 (rs1052133), XRCC1 (rs25489) were analyzed by allele-specific PCR. No associations of studied gene polymorphisms with breast cancer were revealed, as well as interrelations between immunological and genetic parameters in HW. It was detected that levels of IgG specific to benzo[a]pyrene, estradiol and progesterone were associated with the C allele of ADPRT/PARP1 (p=0.02; p=0.003; p=0.006 accordingly). Therefore, it was confirmed that genes of DNA-repair enzymes could determine formation of antibodies specific to the chemical carcinogens and endogenous steroids.

作者简介

E. Polenok

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Email: fake@neicon.ru

PhD (Candidate of Pharmacy), Leading Researcher of Immunochemistry Laboratory,

Kemerovo

俄罗斯联邦

V. Minina

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Email: fake@neicon.ru

MD, Leading Researcher of Cytogenetics Laboratory, 

Kemerovo

俄罗斯联邦

L. Gordeeva

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Email: fake@neicon.ru

PhD (Candidate of Biology), Leading Researcher of Immunogenetics Laboratory,

Kemerovo

俄罗斯联邦

S. Mun

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

编辑信件的主要联系方式.
Email: stellamun@yandex.ru

PhD (Candidate of Medicine), Senior Researcher Fellow of Immunogenetics Laboratory,

Kemerovo

俄罗斯联邦

A. Ryzhkova

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Email: fake@neicon.ru

Leading Engineer-technologist of Cytogenetics Laboratory,

Kemerovo

俄罗斯联邦

A. Glushkov

Novosibirsk State University, Institute of Medicine and Psychology

Email: fake@neicon.ru

Student,

Novosibirsk

俄罗斯联邦

A. Rogozin

Federal Research Center of Coal and Coal chemistry SB RAS, Institute of Human Ecology

Email: fake@neicon.ru

Postgraduate,

Kemerovo

俄罗斯联邦

V. Lutsenko

Regional Clinical Oncology Dispensary

Email: fake@neicon.ru

Main Physician,

Kemerovo

俄罗斯联邦

N. Verzhbitskaya

Regional Clinical Oncology Dispensary

Email: fake@neicon.ru

PhD (Candidate of Medicine), Chief of Path-anatomy Department,

Kemerovo

俄罗斯联邦

I. Vafin

Regional Clinical Oncology Dispensary

Email: fake@neicon.ru

Main Physician,

Kemerovo

俄罗斯联邦

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版权所有 © Polenok E.G., Minina V.I., Gordeeva L.A., Mun S.A., Ryzhkova A.V., Glushkov A.A., Rogozin A.I., Lutsenko V.A., Verzhbitskaya N.E., Vafin I.A., 2019

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