THE INFLUENCE OF A NUMBER OF SUBSTITUTED 1,3,4-6H-THIADIAZINES ON THE CONTENT OF CYTOKINES IN BLOOD PLASMA OF RATS WITH EXPERIMENTAL DIABETES MELLITUS TYPE2

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A study was carried out to investigate the impact of the L-17, a representative of 1,3,4-6H-thiadiazines, on the cytokine spectrum of rat blood plasma when simulating type 2 diabetes mellitus. Doses of nicotinamide and streptozotocin were respectively, 110 mg / kg and 65 mg / kg. The introduction of L-17 to diabetic rats was accompanied by a decrease in hyperglycemia and a partial correction of the imbalance in the content of pro-inflammatory and anti-inflammatory cytokines: a decrease in the level of IL-1α and IFN-γ without normalization of the IL-10 and TGF-β1 level.

作者简介

I. Gette

Ural Federal University named after the first president of Russia B. N. Yeltsin;
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

编辑信件的主要联系方式.
Email: i.goette@yandex.ru

Senior Researcher, Department of Immunochemistry, Institute of Chemical Technology;

PhD, Senior Researcher, Institute of Immunology and Physiology, 

620049, Sverdlovsk Region, Yekaterinburg, st. Pervomaiskaya 106

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V. Emelianov

Ural Federal University named after the first president of Russia B. N. Yeltsin

Email: fake@neicon.ru

PhD, Associate Professor, Department of Immunochemistry, Associate Professor, Department of Medical Biochemistry and Biophysics,

 

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A. Belousova

Ural Federal University named after the first president of Russia B. N. Yeltsin;
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

Laboratory Researcher, Department of Immunochemistry;

Junior Researcher, Institute of Immunology and Physiology, 

Ekaterinburg

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I. Danilova

Ural Federal University named after the first president of Russia B. N. Yeltsin;
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

Head of the Department of Medical Biochemistry and Biophysics;

Doctor of Biological Sciences, Associate Professor, Head of Laboratory of Morphology and Biochemistry,

Ekaterinburg

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L. Sidorova

Ural Federal University named after the first president of Russia B. N. Yeltsin

Email: fake@neicon.ru

Ph.D., Department of Life Safety, 

Ekaterinburg

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T. Tseitler

Ural Federal University named after the first president of Russia B. N. Yeltsin

Email: fake@neicon.ru

Ph.D., Associate Professor of the Department of Organic and Biomolecular Chemistry, 

Ekaterinburg

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版权所有 © Gette I.F., Emelianov V.V., Belousova A.V., Danilova I.G., Sidorova L.P., Tseitler T.A., 2019

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