MOLECULAR COMPONENT-RESOLVED DIAGNOSTICS FOR CAT ALLERGY IN CHILDREN WITH ALLERGIC RHINITIS

Hypersensitivity to cat allergens is a serious clinical problem in many countries because of the high prevalence of these animals. The aim of this study is to assess the spectrum of sensitization to the cat allergen’smolecular components and its role in allergic rhinitis in children. IgE-aB to rFel d 1 were detected in 91.8% of children, to nFel d 2 ‒ in 16.4%, to rFel d 4 ‒ in 43.8% of patients. At the same time ‒ 56.2% of children were monosensitizated to rFel d 1; 27.4% with identifi ed IgE-aB to rFel d 1 and rFel d 4; 8.2% ‒ from IgE-aB to rFel d 1 + nFel d 2 + rFel d 4; and 8.2% ‒ with IgE-aB to nFel d 2 + rFel d 4. Sensitization only to minor allergens did not lead to the development of asthma, but exacerbations of AR in these patients occurred more frequently. To assess the prognosis of the disease and possible reactions to cross-allergens, we recommend component-resolved diagnostics.