IMMUNOLOGICAL PHENOTYPE AND HORMONAL BALANCE IN POSTMENOPAUSAL WOMEN

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Serum concentrations of estradiol (Es) and progesterone (Pg), Es, Pg and benzo[a]pyrene-specific IgA and IgG antibodies were studied in 227 postmenopausal healthy women (HW) and 639 breast cancer patients (BCP). The high individual Pg/Es ratio (> 5.0) was revealed in HW (54.6%) and BCP (26.4%, p < 0.0001, OR = 0.3) marked as “hormonal balance”. The low Pg/Es (≤ 5.0) ratio was detected more frequently in BCP (OR = 3.3) marked as “hormonal imbalance”. The high Pg/Es ratio was more common in HW with protective immunological phenotype (IgA-Bp/IgA-Pg ≤ 1 and IgA-Es/IgA-Pg ≤ 1) than with procarcinogenic immunological phenotype (IgA-Bp/IgA-Pg > 1 and IgA-IgA-Es/IgA-Pg > 1): 78.8 vs 47.4%, p = 0.005. The same parameters for IgG-immunological phenotypes in HW were 73.3 and 48.6%, p = 0.002. The differences between IgA-immunological phenotypes were lowered (41.6 vs 24.4%, p < 0.007), whereas between IgG-phenotypes it was absent in BCP. Thus, for the first time it was revealed the influence of immunological phenotypes based on antibodies specific to the environmental chemical carcinogens and endogenous steroid hormones on the hormonal balance in HW and its reduced effects in BCP.

作者简介

A. Glushkov

Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry

编辑信件的主要联系方式.
Email: stellamun@yandex.ru

Glushkov A.N., PhD, MD (Medicine), Professor, Main Research Associate, Immunogenetics Laboratory

650065, Kemerovo, Leningradsky ave., 10. Phone: 7 (3842) 57-50-79

俄罗斯联邦

E. Polenok

Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry

Email: fake@neicon.ru
Polenok E.G., PhD (Pharmacy), Leading Research Associate, Immunochemistry Laboratory 俄罗斯联邦

S. Mun

Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry

Email: fake@neicon.ru
Mun S.A., PhD (Medicine), Senior Research Associate, Immunogenetics Laboratory 俄罗斯联邦

L. Gordeeva

Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry

Email: fake@neicon.ru
Gordeeva L.A., PhD (Biology), Research Associate, Immunogenetics Laboratory 俄罗斯联邦

M. Kostyanko

Institute of Fundamental Sciences, Kemerovo State University

Email: fake@neicon.ru
Kostyanko M.V., Leading Engineer, Organic Chemistry Department 俄罗斯联邦

V. Lutsenko

Regional Clinical Oncology Dispensary

Email: fake@neicon.ru
Lutsenko V.A., PhD (Medicine), Chief Physician 俄罗斯联邦

G. Kolpinskiy

Kemerovo State Medical University;
Kemerovo Clinical Diagnostic Center

Email: fake@neicon.ru

Kolpinskiy G.I., PhD, MD (Medicine), Professor, Department of Radiology and Radiotherapy with the Course of Oncology

Chief Physician

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E. Brezhneva

Regional Clinical Oncology Dispensary

Email: fake@neicon.ru
Brezhneva E.V., Head, Mammology Department 俄罗斯联邦

I. Vafin

Regional Center of Blood

Email: fake@neicon.ru
Vafin I.A., Chief Physician 俄罗斯联邦

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版权所有 © Glushkov A.N., Polenok E.G., Mun S.A., Gordeeva L.A., Kostyanko M.V., Lutsenko V.A., Kolpinskiy G.I., Brezhneva E.V., Vafin I.A., 2020

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