DETERMINING THE RISK OF THROMBOEMBOLIC COMPLICATIONS IN PATIENTS AFTER CORONARY ARTERY GFAFTING ON THE BASIS OF CLUSTER ANALYSIS

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Ishemic heart disease continues to be the most frequent cause of sluggishness, disability and economic loss in the modern industrial community. At the present time, there is an acute need to use information technologies in evaluating the biochemical processes occurring in the body in the atherosclerotic lesion of arteries in patients with coronary heart disease and as a result of the development of thromboembolic complications of various localizations (heart, brain, lungs) of diff erential diagnostics. 97 patients of both sexes with IHD before and after myocardial revascularization by CABG were examined at the age of 45 to 74 years. The control group consisted of 30 healthy volunteers, comparable in age and sex. Blood sampling was performed a day before the operation, on days 1, 3, 7 and 12 after coronary artery bypass grafting. Cluster analysis was carried out on three revealed indices (TNF-α, MMP-1 and IL-10). Cluster analysis confirmed that the most significant statistically significant changes in the level of TNF-α, IL-10, and MMP-1 were detected in the TEO group. In addition, the increase in TNF-α by 9–10 times and more (from 24 pg / ml) in the preoperative period, IL-10 is higher than 65 pg / ml before operation and from 320 pg / ml on the 1-st day after the operation and increase of MMP-1 in 3 times (from 3.3 ng / ml) before and after CABG is considered to be an additional early marker of the risk of thromboembolic complications after coronary artery bypass grafting.

作者简介

E. Markelova

Pacific State Medical University” of the Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: fake@neicon.ru

MD, professor, Chair of Normal and Pathological Physiology Department,

Vladivostok

俄罗斯联邦

E. Shkorik

Pacific State Medical University” of the Ministry of Health of the Russian Federation

Email: shkorikev@mail.ru

the graduate student of department of Normal and Pathological Physiology Department,

690106, Vladivostok, Ostryakova Avenue 4

俄罗斯联邦

A. Silaev

FSBEI IN “Irkutsk State Medical University” Ministry of healthcare of the Russian Federation

Email: fake@neicon.ru

PhD, MD,

Irkutsk

俄罗斯联邦

O. Zhdanova

FSBIS Automation and Control Processes of FEB RAS

Email: fake@neicon.ru

senior researcher, Doctor of Physico-Mathematical Sciences,

Vladivostok

俄罗斯联邦

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版权所有 © Markelova E.V., Shkorik E.V., Silaev A.A., Zhdanova O.L., 2019

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