ABOUT THE NAKED MOLE RAT LYMPHOID TISSUES
- 作者: Gorshkova E.1,2,3, Gubernatorova E.1,2, Medvedovskaya A.1, Vyssokikh M.4, Holtze S.5, Hildebrandt T.5, Drutskaya M.2, Nedospasov S.1,2,4
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隶属关系:
- Lomonosov Moscow State University
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Belozersky Institute of PhysicoChemical Biology, Lomonosov Moscow State University
- Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University
- Leibniz-Institute for Zoo and Wildlife Research
- 期: 卷 22, 编号 1 (2019)
- 页面: 5-12
- 栏目: ORIGINAL ARTICLES
- URL: https://journals.rcsi.science/1028-7221/article/view/119330
- DOI: https://doi.org/10.31857/S102872210005015-1
- ID: 119330
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全文:
详细
The naked mole-rat (Heterocephalus glaber) is an eusocial rodent living underground, known for its unusually high life expectancy. Biochemical markers of age associated diseases (cancer, neurodegenerative diseases) in naked mole-rat are less pronounced than in other laboratory rodents. The immune system is involved in the aging and carcinogenesis regulation, however, the immune system in the naked mole-rats is yet not investigated well. We found that the immune system of naked mole-rats has structural diff erences compared to a mouse immune system: a smaller number of the bone marrow cells and splenocytes, the small size of the lymphoid follicles of the spleen and lymph nodes, a higher proportion of myeloid cells in the periphery. Taken together, these data provide a basis for studying the fundamental immunity patterns of the naked mole rat, and their contribution to the extraordinary longevity.
作者简介
E. Gorshkova
Lomonosov Moscow State University;Engelhardt Institute of Molecular Biology, Russian Academy of Sciences;
Belozersky Institute of PhysicoChemical Biology, Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: gorshsama@gmail.com
PhD student, Department of Immunology, Biological Faculty,
Moscow
俄罗斯联邦E. Gubernatorova
Lomonosov Moscow State University;Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: fake@neicon.ru
PhD student, Department of Immunology, Biological Faculty,
Moscow
俄罗斯联邦A. Medvedovskaya
Lomonosov Moscow State University
Email: fake@neicon.ru
student, Department of Immunology, Biological Faculty,
Moscow
俄罗斯联邦M. Vyssokikh
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University
Email: fake@neicon.ru
PhD (Biology), head of laboratory,
Moscow
俄罗斯联邦S. Holtze
Leibniz-Institute for Zoo and Wildlife Research
Email: fake@neicon.ru
scientist, Department of Reproduction Management,
Berlin
德国T. Hildebrandt
Leibniz-Institute for Zoo and Wildlife Research
Email: fake@neicon.ru
Professor, head of Reproduction Management Department,
Berlin
德国M. Drutskaya
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: fake@neicon.ru
PhD (Biology), leading researcher,
Moscow
俄罗斯联邦S. Nedospasov
Lomonosov Moscow State University;Engelhardt Institute of Molecular Biology, Russian Academy of Sciences;
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University
Email: sergei.nedospasov@gmail.com
MD (Biology), Professor, academician, head of Department of Immunology, Biological Faculty;
head of laboratory;
head of laboratory,
119334, Moscow, Vavilova srt., 32.
俄罗斯联邦参考
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