Changes of peripheral blood parameters in patients with psoriasis

The issues of widespread psoriasis are quite urgent, due to its high prevalence of this disorder, absence of a single etiopathogenetic concept, diversity of clinical forms and systemic nature of the disease manifestations. Metabolic disorders and biochemical defects play an important role in pathogenesis of psoriasis and may be associated with impaired lipid metabolism. High frequency of dyslipidemia and metabolic syndrome in psoriasis determine high risk of cardiovascular diseases. The study of changes in differential leukocyte counts upon general blood testing and biochemical parameters of peripheral blood in psoriasis is of great clinical and diagnostic importance. The purpose of the study was to evaluate basic laboratory parameters of peripheral blood in patients with psoriasis who underwent inpatient treatment at the all-day Department at Chelyabinsk Regional Clinical Dispensary for Dermato-Venereal Diseases. Laboratory parameters of general and biochemical blood tests were studied in 750 patients with psoriasis admitted to the Dispensary. The severity of psoriasis and clinical PASI index were assessed. The counts of red blood cells, leukocytes, platelets, and hemoglobin were determined in blood as well as RBC color index, erythrocyte sedimentation rate (ESR). We have also assessed the levels of glucose, direct bilirubin, total bilirubin, urea, creatinine, C-reactive protein, rheumatoid factor, cholesterol, and triglycerides in blood serum. The study revealed an increased ESR in elderly patients with severe psoriasis. Dyslipidemia with increased level of cholesterol and triglycerides in the peripheral blood was detected in middle-aged and elderly women and men with moderate-degree psoriasis. In patients with psoriasis over 45 years of age with moderate course of the disease, an excess of total bilirubin was more often observed. An increase in systemic inflammation markers, i.e., C-reactive protein, ESR, direct and total bilirubin is observed in psoriatic disease. Lipid metabolism disorders with increased cholesterol and triglyceride levels were more often observed in moderate course of psoriasis among middle-aged and elderly patients.