Electrochemical Behavior of an Anti-Viral Drug Valacyclovir at Carbon Paste Electrode and Its Analytical Application


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Valacyclovir (VCH) is an antiviral drug, used in the management of viral infections such as herpes simplex and varicella-zoster in humans. It is rapidly converted to acyclovir which has antiviral activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and Varicella-zoster virus (VZV) both in vitro and in vivo. Electrochemical behavior was studied using cyclic voltammetric method, and the analytical application was studied using differential pulse voltammetric technique. The process on the surface of electrode was found to be irreversible and diffusion controlled. The charge transfer coefficient, heterogeneous rate constant, the number of electron transferred and activation parameters were calculated. Possible free radical reaction mechanism taking place on the surface of electrode was proposed. Calibration plot constructed using differential pulse voltammetric technique and applied for quantitative analysis in pharmaceutical and human urine sample. Limit of detection (LOD) and limit of quantification (LOQ) were calculated and found to be 0.028 and 0.09 μM, respectively. The present work describes the electrochemical behavior of an antiviral drug, VCH and its determination in pharmaceutical samples. The method shows the development of a sensor for selective and sensitive determination of VCH.

Sobre autores

Umesh Devarushi

Karnatak University’s Karnatak Science College

Email: sm.tuwar@gmail.com
Índia, Karnataka, Dharwad, 580001

Nagaraj Shetti

Electrochemistry and Materials Group, Department of Chemistry, K.L.E. Institute of Technology, Hubballi-580030

Email: sm.tuwar@gmail.com
Índia, Belagavi, Karanataka

Shikandar Bukkitgar

Electrochemistry and Materials Group, Department of Chemistry, K.L.E. Institute of Technology, Hubballi-580030

Email: sm.tuwar@gmail.com
Índia, Belagavi, Karanataka

Suresh Tuwar

Karnatak University’s Karnatak Science College

Autor responsável pela correspondência
Email: sm.tuwar@gmail.com
Índia, Karnataka, Dharwad, 580001

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