Chromosomal Instability and Karyotype Correction in Human Induced Pluripotent Stem Cells
- 作者: Nikitina T.1, Kashevarova A.1, Lebedev I.1
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隶属关系:
- Research Institute of Medical Genetics, Tomsk National Research Center, Russian Academy of Sciences
- 期: 卷 55, 编号 10 (2019)
- 页面: 1183-1195
- 栏目: Reviews and Theoretical Articles
- URL: https://journals.rcsi.science/1022-7954/article/view/189583
- DOI: https://doi.org/10.1134/S1022795419100090
- ID: 189583
如何引用文章
详细
Human induced pluripotent stem cells (iPSCs) are a promising source of cells for regenerative medicine, study of the pathogenesis of various diseases, screening of pharmacological drugs, and other clinical and basic research. However, the maintenance of the genetic stability of the cells during reprogramming, long-term culture, and directed differentiation is necessary for the use of iPSCs. Large chromosomal aberrations affect the quality of iPSCs most adversely, so the review focuses on the analysis of chromosomal abnormalities, including the recurrent aneuploidy; the sources of its origin, the effect of reprogramming, and long-term culture on the accumulation of chromosome aberrations are discussed. Cases of spontaneous correction of the iPSCs karyotype and the possibility of induced correction of the large chromosomal abnormalities by removing or silencing the extra homologue are considered.
作者简介
T. Nikitina
Research Institute of Medical Genetics, Tomsk National Research Center,Russian Academy of Sciences
编辑信件的主要联系方式.
Email: t.nikitina@medgenetics.ru
俄罗斯联邦, Tomsk, 634050
A. Kashevarova
Research Institute of Medical Genetics, Tomsk National Research Center,Russian Academy of Sciences
Email: t.nikitina@medgenetics.ru
俄罗斯联邦, Tomsk, 634050
I. Lebedev
Research Institute of Medical Genetics, Tomsk National Research Center,Russian Academy of Sciences
Email: t.nikitina@medgenetics.ru
俄罗斯联邦, Tomsk, 634050