Carriage of 2R allele at VNTR polymorphous site of XRCC5 gene increases risk of multiple sclerosis in an Iranian population
- 作者: Jahantigh D.1,2, Moghtaderi A.3, Narooie-Nejad M.4, Mousavi M.5, Moossavi M.6, Salimi S.1,7, Mohammadoo-Khorasani M.8
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隶属关系:
- Cellular and Molecular Research Center
- Department of Biology
- Department of Neurology
- Department of Genetics
- Department of Biology, Faculty of Science
- Genomic Research Center
- Department of Clinical Biochemistry
- Department of Clinical Biochemistry, Faculty of Medical Sciences
- 期: 卷 53, 编号 1 (2017)
- 页面: 147-152
- 栏目: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188071
- DOI: https://doi.org/10.1134/S102279541612005X
- ID: 188071
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The DNA damage has considerably raised in active MS lesions compared to normal brains, indicating the possible role of DNA repairing genes in MS. In the current study, we sought to highlight the association between genetic polymorphisms of XRCC5 and XRCC6 genes, involved in Double Strand Breaks (DSBs) repair, and MS susceptibility. A total of 235 Iranian individuals; including 113 MS patients and 122 healthy controls were participated in this study. They were genotyped for the XRCC5 VNTR polymorphism by polymerase chain reaction (PCR). The genotype analysis of the XRCC6–61C>G polymorphism was performed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The genotypic frequency of 2R/2R in the XRCC5 VNTR polymorphism was significantly higher in MS patients than controls (p = 0.048). The frequency of individuals with 2R allele was statistically significant in MS patients compared to controls (p = 0.041). Moreover, the frequency of 2R allele of the XRCC5 VNTR polymorphism was found to be significantly difference between MS patients and healthy groups (p = 0.003). The present study suggests that the presence of 2R allele in XRCC5 VNTR gene polymorphism may be a genetic risk factor for MS susceptibility in Iranian population.
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作者简介
D. Jahantigh
Cellular and Molecular Research Center; Department of Biology
编辑信件的主要联系方式.
Email: denial_jahantigh@yahoo.com
伊朗伊斯兰共和国, Zahedan, 9816743463; Zahedan, 9816743463
A. Moghtaderi
Department of Neurology
Email: denial_jahantigh@yahoo.com
伊朗伊斯兰共和国, Zahedan, 9816743463
M. Narooie-Nejad
Department of Genetics
Email: denial_jahantigh@yahoo.com
伊朗伊斯兰共和国, Zahedan, 9816743463
M. Mousavi
Department of Biology, Faculty of Science
Email: denial_jahantigh@yahoo.com
伊朗伊斯兰共和国, Zabol
M. Moossavi
Genomic Research Center
Email: denial_jahantigh@yahoo.com
伊朗伊斯兰共和国, Birjand
S. Salimi
Cellular and Molecular Research Center; Department of Clinical Biochemistry
Email: denial_jahantigh@yahoo.com
伊朗伊斯兰共和国, Zahedan, 9816743463; Zahedan, 9816743463
M. Mohammadoo-Khorasani
Department of Clinical Biochemistry, Faculty of Medical Sciences
Email: denial_jahantigh@yahoo.com
伊朗伊斯兰共和国, Tehran