The mechanisms of transgenerational inheritance and their potential contribution to human phenotypes
- 作者: Skoblov M.1,2,3, Scobeyeva V.4, Baranova A.1,3,5,6
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隶属关系:
- Research Center for Medical Genetics
- Evdokimov Moscow State Medical Stomatological University
- Moscow Institute of Physics and Technology
- Department of Biological Evolution
- School of Systems Biology
- Atlas Biomed Group
- 期: 卷 52, 编号 3 (2016)
- 页面: 249-256
- 栏目: Reviews and Theoretical Articles
- URL: https://journals.rcsi.science/1022-7954/article/view/187651
- DOI: https://doi.org/10.1134/S1022795416030145
- ID: 187651
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详细
As of today, classical genetics has already completed the majority of groundwork to describe the laws of inheritance, identify the causes of many human diseases, and dissect the mechanisms of transfer of genetic information from parents to offspring. However, recent studies indicate that inheritance of phenotypic traits may also occur through nongenetic factors, in particular, through epigenetic factors, that manifest their effects in a transgenerational fashion. This review discusses findings in the area of transgenerational inheritance that open a new era in modern genetics. We discuss the mechanisms of transgenerational inheritance, including DNA methylation, histone modifications, and noncoding RNA transfer, and give an overview of the approaches to detect transgenerational effects in humans.
作者简介
M. Skoblov
Research Center for Medical Genetics; Evdokimov Moscow State Medical Stomatological University; Moscow Institute of Physics and Technology
编辑信件的主要联系方式.
Email: mskoblov@generesearch.ru
俄罗斯联邦, Moscow, 115478; Moscow, 127473; Dolgoprudny, Moscow region, 141700
V. Scobeyeva
Department of Biological Evolution
Email: mskoblov@generesearch.ru
俄罗斯联邦, Moscow, 119234
A. Baranova
Research Center for Medical Genetics; Moscow Institute of Physics and Technology; School of Systems Biology; Atlas Biomed Group
Email: mskoblov@generesearch.ru
俄罗斯联邦, Moscow, 115478; Dolgoprudny, Moscow region, 141700; Fairfax, VA, 22030; Moscow, 123317