Bioinformatic Analysis of the Sciatic Nerve Transcriptomes of Mice after 30-Day Spaceflight on Board the Bion-M1 Biosatellite
- Autores: Kuznetsov M.S.1, Rezvyakov P.N.2, Lisyukov A.N.1, Gusev O.A.3,4, Nikolskiy E.E.5,6,7, Islamov R.R.1,7
-
Afiliações:
- Department of Medical Biology and Genetics, Kazan State Medical University
- Department of Normal Anatomy, Kazan State Medical University
- OpenLab Extreme Biology, Kazan (Volga Region) Federal University
- Translational Genomics Unit
- Department of Medical and Biological Physics, Kazan State Medical University
- OpenLab Neuropharmacology, Kazan (Volga Region) Federal University
- Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences
- Edição: Volume 55, Nº 3 (2019)
- Páginas: 388-392
- Seção: Mathematical Models and Methods
- URL: https://journals.rcsi.science/1022-7954/article/view/189294
- DOI: https://doi.org/10.1134/S1022795419030104
- ID: 189294
Citar
Resumo
Comparative bioinformatic analysis of sciatic nerve transcriptomes of C57BL/6J mice was carried out. Animals were divided into three groups: Flight, 30-day spaceflight; Recovery, 30-day spaceflight with subsequent 7-day readaptation; and Control. A significant pool of genes with an absolute difference in expression of more than 32 times compared to the control group was revealed in mice after the 30-day spaceflight (Flight and Recovery groups). Comparative analysis of the Flight and Recovery groups of murine transcriptomes did not reveal any significant differences in gene expression. In animals after spaceflight on board the biosatellite, using the KEGG database (Kyoto Encyclopedia of Genes and Genomes), we identified genes related to the state of metabolic and signaling pathways involved in actin cytoskeleton regulation, regulation of potential-dependent calcium, sodium, and potassium channels, and myelination of nerve fibers.
Sobre autores
M. Kuznetsov
Department of Medical Biology and Genetics, Kazan State Medical University
Autor responsável pela correspondência
Email: qmaxksmu@yandex.ru
Rússia, Kazan, 420012
P. Rezvyakov
Department of Normal Anatomy, Kazan State Medical University
Email: qmaxksmu@yandex.ru
Rússia, Kazan, 420012
A. Lisyukov
Department of Medical Biology and Genetics, Kazan State Medical University
Email: qmaxksmu@yandex.ru
Rússia, Kazan, 420012
O. Gusev
OpenLab Extreme Biology, Kazan (Volga Region) Federal University; Translational Genomics Unit
Email: qmaxksmu@yandex.ru
Rússia, Kazan, 420008; Yokohama City, Riken, 230-0045
E. Nikolskiy
Department of Medical and Biological Physics, Kazan State Medical University; OpenLab Neuropharmacology, Kazan (Volga Region) Federal University; Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences
Email: qmaxksmu@yandex.ru
Rússia, Kazan, 420012; Kazan, 420008; Kazan, 420111
R. Islamov
Department of Medical Biology and Genetics, Kazan State Medical University; Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences
Email: qmaxksmu@yandex.ru
Rússia, Kazan, 420012; Kazan, 420111
Arquivos suplementares
