Отправить статью по E-mail Association of ABCB9 and COL22A1 Gene Polymorphism with Human Predisposition to Severe Forms of Tick-Borne Encephalitis
- Авторы: Barkhash A.V.1, Yurchenko A.A.1, Yudin N.S.1,2, Kozlova I.V.3, Borishchuk I.A.4, Smolnikova M.V.5, Zaitseva O.I.5, Pozdnyakova L.L.6, Voevoda M.I.1,2, Romaschenko A.G.1
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Учреждения:
- Federal Research Center Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
- Novosibirsk State University
- Scientific Centre for Family Health and Human Reproduction Problems
- Irkutsk Regional Infectious Clinical Hospital
- Scientific Research Institute of Medical Problems of the North, Federal Research Center Krasnoyarsk Science Center, Siberian Branch, Russian Academy of Sciences
- City Infectious Clinical Hospital No. 1
- Выпуск: Том 55, № 3 (2019)
- Страницы: 368-377
- Раздел: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/189289
- DOI: https://doi.org/10.1134/S1022795419030025
- ID: 189289
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Аннотация
Tick-borne encephalitis (TBE) is caused by a neurotropic RNA virus from the Flavivirus genus. TBE is characterized by a significant variability of clinical manifestations from nonparalytic forms (fever, meningitis) to severe paralytic (focal) forms (meningoencephalitis, poliomyelitis, polioencephalomyelitis). The result of interaction between a virus and a host (and, consequently, the viral disease course and outcome) largely depends on genetically determined ability of the host (particularly, human) organism immune system to suppress the development of viral infection. However, hereditary predisposition to TBE has been rather poorly studied in human populations. In this study, the results of whole exome sequencing of DNA samples from 22 Russian non-immunized TBE patients with severe TBE forms and 17 control individuals from the same populations are presented. Sixteen single nucleotide polymorphisms (SNPs) associated with predisposition to severe forms of TBE were identified. The genotype and allele frequencies for three of these SNPs localized in the ABCB9 (rs4148866, G/A, intron), COL22A1 (rs4909444, G/T, Ala938Asp), and ITGAL (rs1557672, G/A, intron) genes were then studied in larger samples of patients with different forms of TBE (n = 177) and in the control population (n = 215). As a result, the association of the ABCB9 and COL22A1 gene SNPs with the development of severe forms of TBE was for the first time demonstrated in the Russian population. The hypothesis regarding a possible mechanism of the effect of the ABCB9 gene intronic SNP on the process of human infection with TBE virus is considered.
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Об авторах
A. Barkhash
Federal Research Center Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences
Автор, ответственный за переписку.
Email: barkhash@bionet.nsc.ru
Россия, Novosibirsk, 630090
A. Yurchenko
Federal Research Center Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences
Email: barkhash@bionet.nsc.ru
Россия, Novosibirsk, 630090
N. Yudin
Federal Research Center Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences; Novosibirsk State University
Email: barkhash@bionet.nsc.ru
Россия, Novosibirsk, 630090 ; Novosibirsk, 630090
I. Kozlova
Scientific Centre for Family Health and Human Reproduction Problems
Email: barkhash@bionet.nsc.ru
Россия, Irkutsk, 664003
I. Borishchuk
Irkutsk Regional Infectious Clinical Hospital
Email: barkhash@bionet.nsc.ru
Россия, Irkutsk, 664043
M. Smolnikova
Scientific Research Institute of Medical Problems of the North, Federal Research Center Krasnoyarsk Science Center,Siberian Branch, Russian Academy of Sciences
Email: barkhash@bionet.nsc.ru
Россия, Krasnoyarsk, 660022
O. Zaitseva
Scientific Research Institute of Medical Problems of the North, Federal Research Center Krasnoyarsk Science Center,Siberian Branch, Russian Academy of Sciences
Email: barkhash@bionet.nsc.ru
Россия, Krasnoyarsk, 660022
L. Pozdnyakova
City Infectious Clinical Hospital No. 1
Email: barkhash@bionet.nsc.ru
Россия, Novosibirsk, 630099
M. Voevoda
Federal Research Center Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences; Novosibirsk State University
Email: barkhash@bionet.nsc.ru
Россия, Novosibirsk, 630090 ; Novosibirsk, 630090
A. Romaschenko
Federal Research Center Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences
Email: barkhash@bionet.nsc.ru
Россия, Novosibirsk, 630090
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