Отправить статью по E-mail Polymorphism of genes of the antioxidant system in the development of predispositions to lung cancer
- Авторы: Titov R.A.1, Minina V.I.1,2, Soboleva O.A.1, Ryzhkova A.V.1, Kulemin Y.E.1,2, Voronina E.N.1,3
-
Учреждения:
- Federal Research Center of Coal and Coal Chemistry, Siberian Branch
- Department of Genetics
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
- Выпуск: Том 53, № 8 (2017)
- Страницы: 903-909
- Раздел: Medical Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188397
- DOI: https://doi.org/10.1134/S1022795417080117
- ID: 188397
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
We analyzed the polymorphic loci in the genes of the antioxidant system enzymes, such as GSTP1 (313A>G and 341C>T), MnSOD (47С>Т), GPx1 (599C>T), and CAT (–262C>>T), among 497 residents of Kemerovo oblast (Western Siberia, Russia). The analysis of the single-locus effects demonstrated a significant protective effect of the major C allele in the GPx1 (599C>T) locus. The MDR analysis of the gene-gene interactions showed that the GPx1 and the CAT genes work in close cooperation and mutually reinforce the risk of development of squamous cell lung cancer among the inhabitants of the industrial region.
Ключевые слова
Об авторах
R. Titov
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Автор, ответственный за переписку.
Email: ruslan-tito00@rambler.ru
Россия, Kemerovo, 650065
V. Minina
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Department of Genetics
Email: ruslan-tito00@rambler.ru
Россия, Kemerovo, 650065; Kemerovo, 650043
O. Soboleva
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: ruslan-tito00@rambler.ru
Россия, Kemerovo, 650065
A. Ryzhkova
Federal Research Center of Coal and Coal Chemistry, Siberian Branch
Email: ruslan-tito00@rambler.ru
Россия, Kemerovo, 650065
Yu. Kulemin
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Department of Genetics
Email: ruslan-tito00@rambler.ru
Россия, Kemerovo, 650065; Kemerovo, 650043
E. Voronina
Federal Research Center of Coal and Coal Chemistry, Siberian Branch; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: ruslan-tito00@rambler.ru
Россия, Kemerovo, 650065; Novosibirsk, 630090
Дополнительные файлы
