Genotyping of patients with phenylketonuria from different regions of Russia for determining BH4 responsiveness


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To date, the efficacy of the phenylalanine hydroxylase (PAH) cofactor is proved for the treatment of both BH4-dependent hyperphenylalaninemia and phenylketonuria patients with mutations in the PAH gene. Since the patient’s response depends on the presence of residual PAH enzyme activity, it is advisable to search for mutations in the PAH gene to identify the potential responders and nonresponders to therapy. Four hundred thirty-five phenylketonuria patients from 13 regions of the Russian Federation were genotyped in order to identify responders and nonresponders to tetrahydrobiopterin (BH4) therapy. According to the results of this study, the number of probable nonresponders to the BH4 treatment exceeds 50% owing to a higher overall allelic frequency of “severe” PAH gene mutations. Responder patients with two “mild” mutations in the PAH gene were identified (1.6%).

Sobre autores

P. Gundorova

Research Centre for Medical Genetics

Autor responsável pela correspondência
Email: p_gundorova@inbox.ru
Rússia, Moscow, 115478

A. Stepanova

Research Centre for Medical Genetics

Email: p_gundorova@inbox.ru
Rússia, Moscow, 115478

T. Bushueva

Scientific Center of Children’s Health

Email: p_gundorova@inbox.ru
Rússia, Moscow, 119296

E. Belyashova

Medical and Genetic Counseling

Email: p_gundorova@inbox.ru
Rússia, Orenburg, 460035

R. Zinchenko

Research Centre for Medical Genetics; Pirogov Russian National Research Medical University

Email: p_gundorova@inbox.ru
Rússia, Moscow, 115478; Moscow, 117997

S. Amelina

Rostov State Medical University

Email: p_gundorova@inbox.ru
Rússia, Rostov-on-Don, 344022

S. Kutsev

Research Centre for Medical Genetics; Pirogov Russian National Research Medical University

Email: p_gundorova@inbox.ru
Rússia, Moscow, 115478; Moscow, 117997

A. Polyakov

Research Centre for Medical Genetics

Email: p_gundorova@inbox.ru
Rússia, Moscow, 115478

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