Association of gene polymorphisms of matrix metalloproteinases with reproductive losses in the first trimester of pregnancy
- Авторы: Mashkina E.1, Kovalenko K.1, Marakhovskaya T.1, Saraev K.1, Belanova A.1, Shkurat T.1
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Учреждения:
- Department of Genetics
- Выпуск: Том 52, № 8 (2016)
- Страницы: 853-859
- Раздел: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/187844
- DOI: https://doi.org/10.1134/S1022795416080081
- ID: 187844
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Аннотация
In the present study, the frequencies of genotypes and alleles of candidate genes with respect to polymorphisms associated with increased pregnancy loss in the first trimester of pregnancy, including MMP1–1607insG, MMP9 A–8202G, and TIMP1 С536T, were reported. The frequency of homozygotes for allele MMP9 A–8202 was increased by a factor of two among women with miscarriage in the first trimester compared to the control. Significant models of interaction of genes MMPs and TIMP1 were revealed. The genotypes of genes MMP1 (rs1799750), MMP9 (rs11697325), and TIMP1 (rs11551797) increasing the risk of pregnancy loss in the first trimester were determined.
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E. Mashkina
Department of Genetics
Автор, ответственный за переписку.
Email: lenmash@mail.ru
Россия, Rostov-on-Don, 344090
K. Kovalenko
Department of Genetics
Email: lenmash@mail.ru
Россия, Rostov-on-Don, 344090
T. Marakhovskaya
Department of Genetics
Email: lenmash@mail.ru
Россия, Rostov-on-Don, 344090
K. Saraev
Department of Genetics
Email: lenmash@mail.ru
Россия, Rostov-on-Don, 344090
A. Belanova
Department of Genetics
Email: lenmash@mail.ru
Россия, Rostov-on-Don, 344090
T. Shkurat
Department of Genetics
Email: lenmash@mail.ru
Россия, Rostov-on-Don, 344090