Involvement of MicroRNAs in Regulation of Radioresistance of HeLa and DU145 Cells
- Авторлар: Chebotarev D.A.1, Makhotkin M.A.1, Naboka A.V.1, Tyutyakina M.G.1, Cherkasova E.N.1, Tarasov V.A.1
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Мекемелер:
- Southern Scientific Center, Russian Academy of Sciences
- Шығарылым: Том 55, № 9 (2019)
- Беттер: 1072-1081
- Бөлім: General Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/189532
- DOI: https://doi.org/10.1134/S1022795419090047
- ID: 189532
Дәйексөз келтіру
Аннотация
Using the method of massively parallel sequencing, differential miRNA expression profiles in the original and radioresistant variants of HeLa and DU145 cell lines after radiation exposure at the dose of 4 Gy were obtained. Comparative analysis made it possible to identify a group of miRNAs aberrant expression of which reflected the changes in cell metabolism of radioresistant variants that remained across a number of cell generations as compared to the original ones. The obtained results suggest that the role of miRNAs is associated with the maintenance of functional interaction between DNA methyltransferases, Myc transcription factor, and PTEN phosphatase in regulating the activity of PI3K/AKT and MAPK/ERK signaling pathways. This may underlie differences in realization of radioresistance of HeLa and DU145 cells.
Негізгі сөздер
Авторлар туралы
D. Chebotarev
Southern Scientific Center, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006
M. Makhotkin
Southern Scientific Center, Russian Academy of Sciences
Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006
A. Naboka
Southern Scientific Center, Russian Academy of Sciences
Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006
M. Tyutyakina
Southern Scientific Center, Russian Academy of Sciences
Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006
E. Cherkasova
Southern Scientific Center, Russian Academy of Sciences
Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006
V. Tarasov
Southern Scientific Center, Russian Academy of Sciences
Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006
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