Involvement of MicroRNAs in Regulation of Radioresistance of HeLa and DU145 Cells


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Аннотация

Using the method of massively parallel sequencing, differential miRNA expression profiles in the original and radioresistant variants of HeLa and DU145 cell lines after radiation exposure at the dose of 4 Gy were obtained. Comparative analysis made it possible to identify a group of miRNAs aberrant expression of which reflected the changes in cell metabolism of radioresistant variants that remained across a number of cell generations as compared to the original ones. The obtained results suggest that the role of miRNAs is associated with the maintenance of functional interaction between DNA methyltransferases, Myc transcription factor, and PTEN phosphatase in regulating the activity of PI3K/AKT and MAPK/ERK signaling pathways. This may underlie differences in realization of radioresistance of HeLa and DU145 cells.

Авторлар туралы

D. Chebotarev

Southern Scientific Center, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006

M. Makhotkin

Southern Scientific Center, Russian Academy of Sciences

Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006

A. Naboka

Southern Scientific Center, Russian Academy of Sciences

Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006

M. Tyutyakina

Southern Scientific Center, Russian Academy of Sciences

Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006

E. Cherkasova

Southern Scientific Center, Russian Academy of Sciences

Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006

V. Tarasov

Southern Scientific Center, Russian Academy of Sciences

Email: last-che@yandex.ru
Ресей, Rostov-on-Don, 344006

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