Analysis of heteroplasmy in the major noncoding region of mitochondrial DNA in the blood and atherosclerotic plaques of carotid arteries
- Авторлар: Golubenko M.V.1,2,3, Nazarenko M.S.1,3, Frolov A.V.2, Sleptsov A.A.1,3, Markov A.V.1,3, Glushkova M.E.3, Barbarash O.L.2, Puzyrev V.P.1,3
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Мекемелер:
- Research Institute for Medical Genetics
- Research Institute for Complex Issues of Cardiovascular Diseases
- Laboratory of Human Oncogenetics, Biological Institute
- Шығарылым: Том 52, № 4 (2016)
- Беттер: 436-440
- Бөлім: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/187697
- DOI: https://doi.org/10.1134/S1022795416040049
- ID: 187697
Дәйексөз келтіру
Аннотация
For identification of somatic mitochondrial DNA (mtDNA) mutations, the mtDNA major noncoding region (D-loop) sequence in blood samples and carotid atherosclerosis plaques from patients with atherosclerosis was analyzed. Five point heteroplasmic positions were observed in 4 of 23 individuals (17%). Only in two cases could heteroplasmy have resulted from somatic mutation, whereas three heteroplasmic positions were found in both vascular tissue and blood. In addition, length heteroplasmy in a polycytosine stretches was registered at nucleotide positions 303–315 in 16 individuals, and also in the 16184–16193 region in four patients. The results suggest that somatic mtDNA mutations can occur during atherosclerosis, but some heteroplasmic mutations may appear in all tissues, possibly being inherited.
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Авторлар туралы
M. Golubenko
Research Institute for Medical Genetics; Research Institute for Complex Issues of Cardiovascular Diseases; Laboratory of Human Oncogenetics, Biological Institute
Хат алмасуға жауапты Автор.
Email: maria-golubenko@medgenetics.ru
Ресей, Tomsk, 634050; Kemerovo, 650002; Tomsk, 634050
M. Nazarenko
Research Institute for Medical Genetics; Laboratory of Human Oncogenetics, Biological Institute
Email: maria-golubenko@medgenetics.ru
Ресей, Tomsk, 634050; Tomsk, 634050
A. Frolov
Research Institute for Complex Issues of Cardiovascular Diseases
Email: maria-golubenko@medgenetics.ru
Ресей, Kemerovo, 650002
A. Sleptsov
Research Institute for Medical Genetics; Laboratory of Human Oncogenetics, Biological Institute
Email: maria-golubenko@medgenetics.ru
Ресей, Tomsk, 634050; Tomsk, 634050
A. Markov
Research Institute for Medical Genetics; Laboratory of Human Oncogenetics, Biological Institute
Email: maria-golubenko@medgenetics.ru
Ресей, Tomsk, 634050; Tomsk, 634050
M. Glushkova
Laboratory of Human Oncogenetics, Biological Institute
Email: maria-golubenko@medgenetics.ru
Ресей, Tomsk, 634050
O. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases
Email: maria-golubenko@medgenetics.ru
Ресей, Kemerovo, 650002
V. Puzyrev
Research Institute for Medical Genetics; Laboratory of Human Oncogenetics, Biological Institute
Email: maria-golubenko@medgenetics.ru
Ресей, Tomsk, 634050; Tomsk, 634050
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