The frequency of inactive sucrase-isomaltase variant in indigenous populations of Northeast Asia
- Авторлар: Malyarchuk B.1, Derenko M.1, Denisova G.1
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Мекемелер:
- Institute of Biological Problems of the North, Far Eastern Branch
- Шығарылым: Том 53, № 9 (2017)
- Беттер: 1052-1054
- Бөлім: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/188455
- DOI: https://doi.org/10.1134/S1022795417090095
- ID: 188455
Дәйексөз келтіру
Аннотация
The AG dinucleotide deletion at the rs781470490 locus of the sucrase-isomaltase gene (SI gene), common in the Eskimo people of Canada and Greenland, was screened in the indigenous populations of Northeast Asia (among Chukchi, Koryaks, Evens, and Evenks). Deletion was detected at the frequency of 14.3% (95% confidence interval (CI): 4.7–33.6%) in Chukchi, 7.3% (95% CI: 3.4–14.3%) in Koryaks, and 3.5% (95% CI: 1.3–8.5%) in Evens. Since the deletion at the rs781470490 locus leads to premature termination of the sucrase-isomaltase synthesis and, accordingly, to the appearance of an inactive form of the enzyme, it is suggested that its wide prevalence in populations of the Far North of America and Asia is associated with adaptation to an Arctic diet deficient in sucrose.
Негізгі сөздер
Авторлар туралы
B. Malyarchuk
Institute of Biological Problems of the North, Far Eastern Branch
Хат алмасуға жауапты Автор.
Email: malyarchuk@ibpn.ru
Ресей, Magadan, 685000
M. Derenko
Institute of Biological Problems of the North, Far Eastern Branch
Email: malyarchuk@ibpn.ru
Ресей, Magadan, 685000
G. Denisova
Institute of Biological Problems of the North, Far Eastern Branch
Email: malyarchuk@ibpn.ru
Ресей, Magadan, 685000