Role of allelic genes of matrix metalloproteinases and their tissue inhibitors in the risk of peptic ulcer disease development
- Авторлар: Shaymardanova E.1, Nurgalieva A.1, Khidiyatova I.1, Gabbasova L.2, Kuramshina O.2, Kryukova A.2, Sagitov R.3, Munasipov F.4, Khusnutdinova E.1
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Мекемелер:
- Department of Genetics and Fundamental Medicine
- Department of Polyclinic Therapy
- Emergency Hospital
- Republican Clinical Oncological Dispensary
- Шығарылым: Том 52, № 3 (2016)
- Беттер: 320-330
- Бөлім: Human Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/187666
- DOI: https://doi.org/10.1134/S1022795416020113
- ID: 187666
Дәйексөз келтіру
Аннотация
Peptic ulcer disease is a chronic disease of the gastrointestinal tract, mainly manifesting itself in the formation of the fairly persistent ulcer defect of the mucous membrane of the stomach and/or duodenum. Association analysis of common polymorphisms of matrix metalloproteinases genes MMP-1 (rs1799750, rs494379), MMP-2 (rs2285052), MMP-3 (rs3025058), MMP-9 (rs3918242, rs17576), and MMP-12 (rs2276109) and their tissue inhibitors TIMP-2 (rs8179090) and TIMP-3 (rs9619311) was carried out in 353 patients with a gastric ulcer or duodenal ulcer and in 325 unrelated healthy individuals from the Republic of Bashkortostan. Associations of polymorphic variants rs1799750 and rs494379 of gene MMP-1, rs3025058 of gene MMP-3, rs3918242 and rs17576 of gene MMP-9, and rs9619311 of gene TIMP-3 with the risk of peptic ulcer disease in Russians and Tatars were revealed.
Негізгі сөздер
Авторлар туралы
E. Shaymardanova
Department of Genetics and Fundamental Medicine
Хат алмасуға жауапты Автор.
Email: elza817@mail.ru
Ресей, Ufa, 450076
A. Nurgalieva
Department of Genetics and Fundamental Medicine
Email: elza817@mail.ru
Ресей, Ufa, 450076
I. Khidiyatova
Department of Genetics and Fundamental Medicine
Email: elza817@mail.ru
Ресей, Ufa, 450076
L. Gabbasova
Department of Polyclinic Therapy
Email: elza817@mail.ru
Ресей, Ufa, 450000
O. Kuramshina
Department of Polyclinic Therapy
Email: elza817@mail.ru
Ресей, Ufa, 450000
A. Kryukova
Department of Polyclinic Therapy
Email: elza817@mail.ru
Ресей, Ufa, 450000
R. Sagitov
Emergency Hospital
Email: elza817@mail.ru
Ресей, Ufa, 450000
F. Munasipov
Republican Clinical Oncological Dispensary
Email: elza817@mail.ru
Ресей, Ufa, 450000
E. Khusnutdinova
Department of Genetics and Fundamental Medicine
Email: elza817@mail.ru
Ресей, Ufa, 450076