Molecular-Genetic Mechanisms of Caries Development

Abstract

This review analyzes the literature in the rapidly developing direction of genetic aspects of caries. The search by key words “genetic markers of caries” in the PubMed database was performed. Afterwards, an analysis of the literature lists of found publications was completed and additional sources were studied. Search by “caries” on the platform of elibrary.ru was performed. From the published data, the role of markers by spectrum of genes in caries development is obvious; however, the development of caries is influenced not only by genetic factors but also by environmental factors. The established molecular-genetic markers of caries development, including genes connected with immunity, saliva content, and rate of saliva formation and also connected with formation of teeth, dentin, and tooth enamel are considered. Social demographic factors and environmental factors (dietary peculiarities, hygiene of mouth cavity, contamination of environment, content of mouth microbiota) influencing caries development are considered. Information from literature sources will help to characterize the modern understanding of caries development and will also make it possible to perform both individual and population screening aiming to develop novel methods of caries prevention taking into account the detected markers of caries, establish groups of risk, and apply a personalized approach in the treatment of the disease.