Antigenotoxic activity of biologically active substances from Inula britannica and Limonium gmelini
- Authors: Lovinskaya A.V.1, Kolumbayeva S.Z.1, Shalakhmetova T.M.1, Marsova M.V.2, Abilev S.K.2,3
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Affiliations:
- Al-Farabi Kazakh National University
- Vavilov Institute of General Genetics
- Department of Genetics
- Issue: Vol 53, No 12 (2017)
- Pages: 1311-1319
- Section: General Genetics
- URL: https://journals.rcsi.science/1022-7954/article/view/188547
- DOI: https://doi.org/10.1134/S1022795417120080
- ID: 188547
Cite item
Abstract
The antigenotoxic and antioxidant activities of biologically active substances of extracts from Inula britannica L. and Limonium gmelinii (Willd.) Kuntze in E. coli strains MG1655 (pColD-lux), MG1655 (pSoxS-lux), and MG1655 (pKatG-lux) were studied by the bioluminescent test. Plant extracts from I. britannica and L. gmelinii in all used concentrations (0.5, 5.0, 50.0, and 500.0 μg/mL) had no genotoxic or oxidant activity. The extracts statistically significantly reduced the bioluminescence intensity of the pColD-lux, pKatG-lux, and pSoxS-lux sensors (p < 0.05) induced by 4-NQO and dioxidine, hydrogen peroxide, and paraquat, respectively. The activity of the extracts depended on their concentration; the greatest antigenotoxic and antioxidant effects were detected at a concentration of 500.0 μg/mL.
About the authors
A. V. Lovinskaya
Al-Farabi Kazakh National University
Author for correspondence.
Email: annalovinska@rambler.ru
Kazakhstan, Almaty, 050040
S. Zh. Kolumbayeva
Al-Farabi Kazakh National University
Email: annalovinska@rambler.ru
Kazakhstan, Almaty, 050040
T. M. Shalakhmetova
Al-Farabi Kazakh National University
Email: annalovinska@rambler.ru
Kazakhstan, Almaty, 050040
M. V. Marsova
Vavilov Institute of General Genetics
Email: annalovinska@rambler.ru
Russian Federation, Moscow, 119991
S. K. Abilev
Vavilov Institute of General Genetics; Department of Genetics
Email: annalovinska@rambler.ru
Russian Federation, Moscow, 119991; Moscow, 119991