Mod(mdg4)-58.0, the product of mod(mdg4) locus, directly interacts with kermit protein of Drosophila melanogaster

Abstract

The experiments in a yeast two-hybrid system, on co-immunoprecipitation of proteins from the D. melanogaster embryonic cell lysates, and on cell immunostaining have shown for the first time that the product of mod(mdg4) locus, Mod (mdg4)-58.0 (isoform C), directly interacts with Kermit protein (dGIPC). Kermit protein plays an important role in locomotor activity, polarization of the cells within the plane of the epithelium at the early stages of development, transfer of intercellular signals, and determining the longevity of Drosophila. These data expand the understanding of the role of Mod(mdg4)-58.0 protein in the eukaryotic cell activity.