Impurities of [1-13C]Pyruvic Acid and a Method to Minimize Their Signals for Hyperpolarized Pyruvate Metabolism Studies


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Impurities are a necessary evil when working with hyperpolarized [1-13C]pyruvate for real-time metabolic studies. We show that the impurities’ spectrum persists throughout the detection window as these signals show a long T1. At the same time, the impurities’ spectrum is unpredictable and partly susceptible to minute pH changes in the microenvironment such that impurities’ signals may overlap with hyperpolarized metabolite signals. We show a method to eliminate the hyperpolarized impurities’ signals while maintaining sufficient hyperpolarized [1-13C]pyruvate signal for metabolic studies.

作者简介

Talia Harris

Department of Radiology, Hadassah-Hebrew University Medical Center

Email: rkb@hadassah.org.il
以色列, Jerusalem, 9112001

Ayelet Gamliel

Department of Radiology, Hadassah-Hebrew University Medical Center

Email: rkb@hadassah.org.il
以色列, Jerusalem, 9112001

Jacob Sosna

Department of Radiology, Hadassah-Hebrew University Medical Center

Email: rkb@hadassah.org.il
以色列, Jerusalem, 9112001

J. Gomori

Department of Radiology, Hadassah-Hebrew University Medical Center

Email: rkb@hadassah.org.il
以色列, Jerusalem, 9112001

Rachel Katz-Brull

Department of Radiology, Hadassah-Hebrew University Medical Center

编辑信件的主要联系方式.
Email: rkb@hadassah.org.il
ORCID iD: 0000-0003-4850-1616
以色列, Jerusalem, 9112001

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