Отправить статью по E-mail 31P MRS Study of Hyperbaric Oxygenation Effects on Phosphate Metabolism of Normal Human Brain
- Авторы: Manzhurtsev A.V.1,2, Vasiukova O.R.2, Sergeeva V.V.2, Zaitseva N.L.2, Menshchikov P.E.2, Melnikov I.A.2, Akhadov T.A.2, Semenova N.A.1,2,3
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Учреждения:
- N.M. Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences
- Clinical and Research Institute of Emergency Pediatric Surgery and Trauma
- N.N. Semenov Institute of Chemical Physics of the Russian Academy of Sciences
- Выпуск: Том 49, № 7 (2018)
- Страницы: 679-686
- Раздел: Original Paper
- URL: https://journals.rcsi.science/0937-9347/article/view/248108
- DOI: https://doi.org/10.1007/s00723-018-1019-9
- ID: 248108
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Аннотация
For the first time, the effects of one hyperbaric oxygenation (HBO) session on cellular phosphate metabolite levels and pH were investigated in vivo. 31P magnetic resonance spectroscopy was used in this study. The optimized protocol of Image-Selected Invivo Spectroscopy pulse sequence for 31P MRS was applied to increase SNR of ATP resonances. An activation of energy metabolism that manifested in the decrease of creatine phosphate and pHint after an HBO session is revealed. The growth of the α-ATP signal is elucidated as well, while other ATP resonances remain unchanged. This might reflect the increase in nicotinamide adenine dinucleotide (NAD) concentration. The rise of its level as well as the detected creatine phosphate expenses immediately after HBO may denote the activation of fast NAD synthesis pathways.
Об авторах
A. Manzhurtsev
N.M. Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences; Clinical and Research Institute of Emergency Pediatric Surgery and Trauma
Автор, ответственный за переписку.
Email: andrey.man.93@gmail.com
ORCID iD: 0000-0001-5022-9952
Россия, 4, Kosygina st., Moscow, 119334; 22, Bol’shaya Polyanka st., Moscow, 119180
O. Vasiukova
Clinical and Research Institute of Emergency Pediatric Surgery and Trauma
Email: andrey.man.93@gmail.com
Россия, 22, Bol’shaya Polyanka st., Moscow, 119180
V. Sergeeva
Clinical and Research Institute of Emergency Pediatric Surgery and Trauma
Email: andrey.man.93@gmail.com
Россия, 22, Bol’shaya Polyanka st., Moscow, 119180
N. Zaitseva
Clinical and Research Institute of Emergency Pediatric Surgery and Trauma
Email: andrey.man.93@gmail.com
Россия, 22, Bol’shaya Polyanka st., Moscow, 119180
P. Menshchikov
Clinical and Research Institute of Emergency Pediatric Surgery and Trauma
Email: andrey.man.93@gmail.com
Россия, 22, Bol’shaya Polyanka st., Moscow, 119180
I. Melnikov
Clinical and Research Institute of Emergency Pediatric Surgery and Trauma
Email: andrey.man.93@gmail.com
Россия, 22, Bol’shaya Polyanka st., Moscow, 119180
T. Akhadov
Clinical and Research Institute of Emergency Pediatric Surgery and Trauma
Email: andrey.man.93@gmail.com
Россия, 22, Bol’shaya Polyanka st., Moscow, 119180
N. Semenova
N.M. Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences; Clinical and Research Institute of Emergency Pediatric Surgery and Trauma; N.N. Semenov Institute of Chemical Physics of the Russian Academy of Sciences
Email: andrey.man.93@gmail.com
Россия, 4, Kosygina st., Moscow, 119334; 22, Bol’shaya Polyanka st., Moscow, 119180; 4, Kosygina st., Moscow, 119334
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