Zinc–Nickel Ferrite Nanoparticles as a Contrast Agent in Magnetic Resonance Imaging
- Авторы: Sattarahmady N.1,2, Heidari M.1, Zare T.1, Lotfi M.3, Heli H.1
-
Учреждения:
- Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences
- Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences
- Department of Radiology, Shiraz University of Medical Sciences
- Выпуск: Том 47, № 8 (2016)
- Страницы: 925-935
- Раздел: Article
- URL: https://journals.rcsi.science/0937-9347/article/view/247511
- DOI: https://doi.org/10.1007/s00723-016-0801-9
- ID: 247511
Цитировать
Аннотация
Today, contrast agents are used to improve the sensitivity of magnetic resonance imaging (MRI) to detect pathologic structures. Ferrite nanoparticles are a class of superparamagnetic contrast agents in MRI. In this study, Zn0.5Ni0.5Fe2O4 nanoparticles were synthesized via precipitation method and coated with dextrin to increase the solubility and biocompatibility. The morphology, size, structure, and magnetic properties of nanoparticles were investigated. These nanoparticles have superparamagnetic property with a narrow size distribution with a mean diameter of about 20.5 ± 3.2 nm. MRI study using phantom agar shows that these nanoparticles can be used as an effective contrast agent for T2 and \(T_{2}^{*}\)-weighted imaging. The relaxivities of r2 and \(r_{2}^{*}\) are 8.78 and 82.08 s−1 mmol L−1, respectively. From these findings, it is possible that dextrin-coated Zn0.5Ni0.5Fe2O4 nanoparticles can be used as a good negative contrast agent in MRI.
Ключевые слова
Об авторах
N. Sattarahmady
Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences; Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences
Email: hheli7@yahoo.com
Иран, Shiraz; Shiraz
M. Heidari
Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences
Email: hheli7@yahoo.com
Иран, Shiraz
T. Zare
Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences
Email: hheli7@yahoo.com
Иран, Shiraz
M. Lotfi
Department of Radiology, Shiraz University of Medical Sciences
Email: hheli7@yahoo.com
Иран, Shiraz
H. Heli
Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences
Автор, ответственный за переписку.
Email: hheli7@yahoo.com
Иран, Shiraz