Elaboration of New Treatment Methods for Spinal Cord Injuries Using Magnetic Nanoparticles in Combination with Electromagnetic Field (Experimental Study)

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The latest studies on the use of magnetic nanoparticles (MNP) in biological systems prove their high biocompatibility and possibility to interact with various types of cells including the neurons. This may serve as a basis for potential restoration of the neuronal network after nerve tissue integrity damage. The purpose of the study was to determine the influence of MNP on the restoration of hind paws function in experimental animals after spinal cord transection (by 50, 80 and 100%) under the influence of a magnetic field. Magnetic nanoparticles were inserted into the injury zone via plastic catheter. The degree of function loss and its subsequent restoration was assessed by BBB Locomotor Scale and induced potentials on the first postoperative day and then weekly within one month. Statistically significant (p<0.001) increase of both the induced potentials’ amplitude and mean functional indices was reordered only in group with 50% spinal cord transection. Also in that group the less marked scar changes and the highest neuronal cells survival rate was observed. Use of MNP under the influence of external magnetic field promotes the restoration of motor function and increases the conductivity of injured spinal cord tissues in experimental animals in the mean long term period. The mechanism of such restoration needs further study.

作者简介

S. Kolesov

N.N. Priorov Central Institute of Traumatology and Orthopaedics

доктор мед. наук, профессор, зав. отделением патологии позвоночника ЦИТО Moscow, Russia

A. Panteleev

N.N. Priorov Central Institute of Traumatology and Orthopaedics

ординатор ЦИТО Moscow, Russia

M. Sazhnev

N.N. Priorov Central Institute of Traumatology and Orthopaedics

Email: mak.sajnev@yandex.ru
кандидат мед. наук, врач отделения патологии позвоночника; Тел.: 8 (495) 450-44-51 Moscow, Russia

A. Kaz’min

N.N. Priorov Central Institute of Traumatology and Orthopaedics

кандидат мед. наук, врач отделения патологии позвоночника Moscow, Russia

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