CONSEQUENCES OF RADIATION THERAPY OF ONCOLOGICAL DISEASES: FOCUS ON PERICARDITIS


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Abstract

Radiation exposure of the chest is associated with a significant risk of subsequent development of cardiovascular diseases. Associated cardiovascular injuries include pericardial disease, coronary artery disease, valvular disease, conduction disease, cardiomyopathy, and vasculopathy. This article presents the development of different variants of pericardial radiation damage, methods of diagnosis and treatment of these complications. Radiation damage to the pericardium can manifest as acute pericarditis, effusion with tamponade or without cardiac tamponade, effusion-constrictive or classic constrictive pericarditis. Algorithms for the diagnosis and treatment of patients with radiation pericarditis in connection with a long asymptomatic course in a number of patients deserve special attention. Careful history taking and identifying prior radiotherapy is important in this category of patients. Untimely diagnosis and late treatment of these complications leads to a decrease in the quality of life of patients and increases the risk of cardiovascular mortality.

About the authors

E. I Emelina

N. I. Pirogov Russian National Research Medical University”

117997, Moscow, Russian Federation

A. A Ibragimova

N. I. Pirogov Russian National Research Medical University”

117997, Moscow, Russian Federation

P. A Dreval

Moscow City Oncological Hospital №62 of the Moscow Healthcare Department

143423, Moscow, Russian Federation

Gennady E. Gendlin

N. I. Pirogov Russian National Research Medical University”

Email: rgmugt2@mail.ru
doktor of medical sciences, professor, Department of Hospital Therapy № 2 “N. I. Pirogov Russian National Research Medical University”; 117997, Moscow, Russian Federation 117997, Moscow, Russian Federation

I. G Nikitin

N. I. Pirogov Russian National Research Medical University”

117997, Moscow, Russian Federation

I. E Byalik

I.M. Sechenov First Moscow State Medical University

119992, Moscow, Russian Federation

E. A Antuch

Moscow City Oncological Hospital №62 of the Moscow Healthcare Department

143423, Moscow, Russian Federation

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