Pharmacokinetics of Verapamil and Hemodynamic Indices during Head-down Bed Rest
- 作者: Bogomolov V.1, Kondratenko S.2, Polyakov A.1, Kovachevich I.1, Repenkova L.1
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隶属关系:
- Institute of Medical and Biological Problems
- Sechenov First Moscow State Medical University
- 期: 卷 45, 编号 7 (2019)
- 页面: 781-785
- 栏目: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/178444
- DOI: https://doi.org/10.1134/S036211971907003X
- ID: 178444
如何引用文章
详细
The purpose of this work was to study the pharmacokinetics of the Ca ion antagonist verapamil (a single dose of 80 mg) and hemodynamics in nine volunteers with normal life activities (experiment 1) and on the second day of head-down (–8°) bed rest (experiment 2). The plasma concentration of verapamil was measured using high-performance liquid chromatography with fluorometric detection. Heart rate (HR), cardiac output (CO), stroke volume (SV) and general peripheral vascular resistance (GPVR) were measured using integral rheography according to Tishchenko (Mingograf-410, Russia); blood pressure (BP) was measured by Korotkoff sounds. Analysis of verapamil pharmacokinetics in both experiments showed identity of the averaged curve profiles that did not differ significantly. The pharmacokinetic parameters were comparable. Based on hemodynamics analysis, HR elevation 1 h after verapamil administration was the most common reaction in both experiments; a short CO rise and GPVR decrease were observed in experiment 2 1 h after administration. These hemodynamic shifts were not pathologic and did not deviate from the physiological range in healthy people; changes in verapamil pharmacokinetics were also not detected. These findings provide the grounds to recommend verapamil for rational pharmacotherapy of cardiovascular diseases that may develop in piloted space missions.
作者简介
V. Bogomolov
Institute of Medical and Biological Problems
Email: repenkova@imbp.ru
俄罗斯联邦, Moscow, 123007
S. Kondratenko
Sechenov First Moscow State Medical University
Email: repenkova@imbp.ru
俄罗斯联邦, Moscow
A. Polyakov
Institute of Medical and Biological Problems
Email: repenkova@imbp.ru
俄罗斯联邦, Moscow, 123007
I. Kovachevich
Institute of Medical and Biological Problems
Email: repenkova@imbp.ru
俄罗斯联邦, Moscow, 123007
L. Repenkova
Institute of Medical and Biological Problems
编辑信件的主要联系方式.
Email: repenkova@imbp.ru
俄罗斯联邦, Moscow, 123007